New formula for predicting mean pulmonary artery pressure using systolic pulmonary artery pressure
New formula for predicting mean pulmonary artery pressure using systolic pulmonary artery pressure
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DOI：
10.1378/chest.126.4.1313
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发表时间：
2004-10-01
期刊：
影响因子：
9.6
通讯作者：
Hervé, P
中科院分区：
文献类型：
--
作者：
Chemla, D;Castelain, V;Hervé, P
研究目的：平均肺动脉压（MPAP）和收缩期肺动脉压（SPAP）可互换用于定义肺动脉高压（PH）。我们测试的假设，即测量MPAP和SPAP是多余的，在休息的人在一个广泛的压力范围。设计：前瞻性，观察性研究。设置：导管实验室在一所大学医院。患者：这项研究涉及31名患者，如下：原发性PH，9名患者，慢性肺血栓栓塞症，7名患者，静脉PH，6名患者。和肺动脉压正常的对照组，9名患者。干预：无。测量和结果：在患者休息时获得高保真度肺动脉压。在所研究的广泛MPAP范围内（10至78 mm Hg），MPAP和SPAP密切相关（r（2）= 0.98）。对前16名受试者（测试样本）进行的回归分析使我们能够提出一个公式（MPAP = 0.61 SPAP + 2 min Hg），其准确性在其余15名受试者中得到证实（验证样本偏倚，0 +/- 2 min Hg）。如果PH由SPAP超过30或40 mm Hg定义，则这对应于MPAP超过20或26 mm Hg。如果PH被定义为MPAP> 25毫米汞柱，这对应于SPAP> 38分钟Hg.Conclusions：在休息的人，MPAP可以准确地预测从SPAP在很宽的压力范围。新的公式可能有助于改进用于PH诊断的阈值压力值。需要进一步的研究来检验我们的公式可能允许从多普勒衍生SPAP值无创预测MPAP的假设。
Study objectives: Mean pulmonary artery pressure (MPAP) and systolic pulmonary artery pressure (SPAP) are used interchangeably to define pulmonary hypertension (PH). We tested the hypothesis that the measurement of MPAP and SPAP is redundant in resting humans over a wide pressure range.Design: Prospective, observational study.Setting: Catheteirization laboratory in a university hospital.Patients: This study involved 31 patients, as follows: primary PH, nine patients; chronic pulmonary thromboembolism, seven patients; venous PH, six patients; and control subjects with normal pulmonary artery pressure, nine patients. Interventions: None.Measurements and results: High-fidelity pulmonary artery pressures were obtained when patients were at rest. Over the wide MPAP range that was under study (10 to 78 mm Hg), MPAP and SPAP were strongly related (r(2) = 0.98). Regression analysis performed on the first 16 subjects (test sample) allowed us to propose a formula (MPAP = 0.61 SPAP + 2 min Hg), the accuracy of which was confirmed in the remaining 15 subjects (validation sample bias, 0 +/- 2 min Hg). If PH was defined by an SPAP in excess of 30 or 40 mm Hg, this corresponded to an MPAP in excess of 20 or 26 mm Hg. If PH was defined by an MPAP of > 25 mm Hg, this corresponded to an SPAP of > 38 min Hg.Conclusions: In resting humans, MPAP can be accurately predicted from SPAP over a wide pressure range. The new formula may help to refine the threshold pressure values used in the diagnosis of PH. Further studies are needed to test the hypothesis that our formula may allow the noninvasive prediction of MPAP from Doppler-derived SPAP values.