The effects of hormone replacement therapy on carbohydrate metabolism and cardiovascular risk factors in surgically postmenopausal cynomolgus monkeys.
The effects of hormone replacement therapy on carbohydrate metabolism and cardiovascular risk factors in surgically postmenopausal cynomolgus monkeys.
复制标题
激素替代疗法对绝经后食蟹猴碳水化合物代谢和心血管危险因素的影响。
DOI：
10.1016/s0026-0495(96)90244-9
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Cefalu,WT
中科院分区：
文献类型：
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作者：
Wagner,JD;Martino,MA;Jayo,MJ;Anthony,MS;Clarkson,TB;Cefalu,WT
关于雌激素和雌激素/黄体酮替代疗法对葡萄糖耐量和胰岛素抵抗的影响存在争议。同样未知的是，激素治疗后葡萄糖耐量和胰岛素抵抗的改变是否会影响动脉糖化和动脉粥样硬化。我们研究了切除卵巢的雌性猴子，喂食降脂饮食，不给予激素替代疗法（n = 25）或单独使用马雌激素（n = 22）或联合使用醋酸甲羟孕酮（[MPA] n = 21） 30个月。与对照组或单独给予雌激素的猴子相比，接受联合激素替代的猴子的空腹血糖和胰岛素水平明显更高，对葡萄糖挑战的胰岛素反应也更高。只接受雌激素治疗的猴子体重较低，腹部脂肪含量较低，血清雄激素浓度降低。然而，由于有效的饮食脂质降低，激素治疗对动脉粥样硬化没有额外的影响。此外，动脉糖化或胰岛素水平与动脉粥样硬化程度之间没有相关性。因此，尽管联合激素替代疗法对碳水化合物代谢有不良影响，但我们无法确定这些影响是否改变了动脉粥样硬化的程度。
Controversy exists regarding the effects of estrogen and estrogen/progestin replacement therapies on glucose tolerance and insulin resistance. Also unknown are whether changes in glucose tolerance and insulin resistance with hormone therapy affect arterial glycation and atherosclerosis. We studied ovariectomized female monkeys fed a lipid-lowering diet and given either no hormone replacement therapy (n = 25) or conjugated equine estrogens (CEE) alone (n = 22) or combined with medroxyprogesterone acetate ([MPA] n = 21) for 30 months. Monkeys receiving combined hormone replacement had significantly higher fasting glucose and insulin levels and higher insulin responses to a glucose challenge compared with controls or those given estrogen alone. Monkeys given estrogen-only therapy had lower body weights, lower measures of abdominal adiposity, and decreased serum androgen concentrations. However, due to the effective dietary lipid decrease, there was no additional effect of hormone treatment on atherosclerosis. Also, there was no correlation between either arterial glycation or insulin levels and atherosclerosis extent. Thus, although there were adverse effects of combined hormone replacement therapy on carbohydrate metabolism, we were unable to determine whether these effects altered the extent of atherosclerosis.