Surgical results and prognosis of lung cancer in elderly Japanese patients aged over 85 years: comparison with patients aged 80-84 years
Surgical results and prognosis of lung cancer in elderly Japanese patients aged over 85 years: comparison with patients aged 80-84 years
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DOI：
10.1007/s11748-020-01426-y
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发表时间：
2020-07-05
影响因子：
1.2
通讯作者：
Suzuki, Kenji
中科院分区：
文献类型：
--
作者：
Ichinokawa, Hideomi;Takamochi, Kazuya;Suzuki, Kenji
目的随着80岁以上肺癌患者的增多，一般情况良好的患者常接受肺叶切除联合纵隔淋巴结清扫术。然而，该手术的年龄限制尚未确定。在这项研究中，我们检查了 85 岁以上肺癌患者手术治疗的安全性、治疗结果和预后。方法 1997年1月至2019年3月在我院接受手术的4446例肺癌患者中，我们评估了320例患者（7.2%，A组，年龄80-84岁）和74例患者（1.7%，B组，年龄85岁以上）。结果B组患者的中位年龄为86岁。与A组相比，B组有缺血性心脏病史、包年吸烟率较低、肺叶切除及肺叶切除较少切除（减少手术）的患者明显较多，手术时间较短（P < 0.05）。两组术后并发症无显着差异。两组生存率和预后无显着差异，B组2年、3年和5年生存率分别为79.0%、74.7%和53.6%。B组中性别（女性）和癌症早期分期是非小细胞肺癌（I期）的独立预后因素。结论 在有限的患者中，85岁以上患者的手术切除是安全的，且这些患者的生存率与80-84岁患者相当。
Objective With the increase in lung cancer patients over 80 years of age, lobectomy with mediastinal lymph node dissection is often performed in patients in a good general condition. However, the age limit for this procedure has not yet been determined. In this study, we examined the safety, therapeutic results, and prognosis of surgical treatment for lung cancer patients over 85 years of age. Methods Among the 4446 lung cancer patients who underwent surgery at our hospital from January 1997 to March 2019, we assessed 320 patients (7.2%, Group A, aged 80-84 years) and 74 patients (1.7%, Group B, aged over 85 years). Results The median age of the patients in Group B was 86 years. Compared to Group A, Group B had significantly more patients with a history of ischemic heart disease, lower pack-year smoking, and lobectomy and lobectomy less resection (reduced surgery), and a shorter operation time (P < 0.05). There was no significant difference between the two groups in terms of postoperative complications. There was no significant difference in survival rate and prognosis between the two groups, and the 2-, 3-, and 5-year survival rates were 79.0%, 74.7%, and 53.6%, respectively, in Group B. In Group B sex (female) and early stage of cancer were independent prognostic factors of non-small cell lung cancer (stage I). Conclusions In a limited number of patients, surgical resection in patients aged over 85 years was safely performed, and the survival of these patients was comparable to those aged 80-84 years.