MALDI-TOF mass spectrometry in the analysis of synthetic polymers
MALDI-TOF mass spectrometry in the analysis of synthetic polymers
复制标题
MALDI-TOF 质谱法在合成聚合物分析中的应用
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
W. Schrepp
中科院分区：
文献类型：
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作者：
H. Räder;W. Schrepp
在过去的5年里，基质辅助激光解吸/电离质谱仪在合成聚合物的分析中取得了越来越大的成功。叙述了影响光谱的基本原理和仪器参数。从聚合物研究的不同领域，特别是与技术相关的系统的例子，阐明了这种质谱学的高度有用的特点，即测定绝对摩尔质量，高质量范围，合理的质量分辨率，高灵敏度，即使对极性分子也相对容易操作。摩尔质量分布可以在质量范围内获得，这对其他质量测定技术是有问题的。在许多情况下，通过端基分析可以获得基本化学的详细表征。特别是与其他分离技术相结合，可以实现对化学非均质性的全面表征。最近的发展，如延迟提取以提高可获得的质量分辨率，将进一步增加这一技术的良好前景。
Matrix-assisted laser desorption/ionization mass spectrometry has been applied over the past 5 years with increasing success to the analysis of synthetic polymers. Basic principles and instrumental parameters influencing the spectra are described. Examples from different areas of polymer research with emphasis on technically relevant systems elucidate the highly useful features of this kind of mass spectrometry, i. e. determination of absolute molar masses, high mass range, reasonable mass resolution, high sensitivity, relative ease of operation even for polar molecules. Molar mass distributions can be obtained in a mass range that is problematic for other mass determining techniques. A detailed characterization of the underlying chemistry can be obtained in many cases by an endgroup analysis. Especially in combination with other separation techniques, a comprehensive characterization of chemical heterogeneity can be achieved. Recent developments, e. g. delayed extraction to enhance the mass resolution obtainable, will further increase the favorable prospects of this technique.