Phase Transitions of Associative Biomacromolecules.
Phase Transitions of Associative Biomacromolecules.
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DOI：
10.1021/acs.chemrev.2c00814
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发表时间：
2023-03
期刊：
影响因子：
62.1
通讯作者：
R. Pappu;Samuel R. Cohen;Furqan Dar;M. Farag;Mrityunjoy Kar
中科院分区：
文献类型：
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作者：
R. Pappu;Samuel R. Cohen;Furqan Dar;M. Farag;Mrityunjoy Kar
多价蛋白质和核酸统称为多价缔合生物大分子，为生物分子凝聚体的形成和组成调节提供驱动力。在这里，我们回顾了缔合生物大分子水溶液相变的关键概念，特别是包括折叠域和本质无序区域的蛋白质。这些系统的相变属于耦合缔合和分离相变的范畴。介绍了这些过程的基本概念，并讨论了它们与生物分子凝聚体的相关性。
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative biomacromolecules, provide the driving forces for the formation and compositional regulation of biomolecular condensates. Here, we review the key concepts of phase transitions of aqueous solutions of associative biomacromolecules, specifically proteins that include folded domains and intrinsically disordered regions. The phase transitions of these systems come under the rubric of coupled associative and segregative transitions. The concepts underlying these processes are presented, and their relevance to biomolecular condensates is discussed.