COX-2 Is Associated with Periodontitis in Europeans
COX-2 Is Associated with Periodontitis in Europeans
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DOI：
10.1177/0022034509359575
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发表时间：
2010-04-01
影响因子：
7.6
通讯作者：
Schreiber, S.
中科院分区：
文献类型：
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作者：
Schaefer, A. S.;Richter, G. M.;Schreiber, S.
COX-2通过介导牙周组织中的炎症反应在牙周炎中起重要作用，已有报道称COX-2基因rs20417和rs689466与台湾和华裔人群的牙周炎有关。为了测试这些变异是否与欧洲人种人群中的牙周炎有关，我们对侵袭性(n=532)和慢性牙周炎(n=1052)和2873名健康对照个体的单核苷酸多态(SNPs)rs689466和rs6681231进行了基因分型，后者是rs20417(r(2)>；0.95)的单倍型标记SNP(HtSNP)。在调整吸烟、糖尿病和性别的协变量前后，hTSNP rs6681231罕见的G等位基因与侵袭性牙周炎相关，优势比为1.57(95%可信区间为1.18-2.08；p=0.002)。HSNP rs6681231对rs20417关联的验证为COX-2变异在牙周炎发病机制中的一般遗传风险提供了证据。
COX-2 plays an important role in periodontitis by mediating inflammatory reactions in periodontal tissues, and the COX-2 polymorphisms rs20417 and rs689466 have been reported to be associated with periodontitis in populations of Taiwanese and Chinese ethnicity. To test whether these variants were associated with periodontitis in populations of European ethnicity, we genotyped the single-nucleotide polymorphisms (SNPs) rs689466 and rs6681231, the latter a haplotype tagging SNP (htSNP) for rs20417 (r(2)>0.95), in our large-analysis population of individuals with aggressive (n = 532) and chronic periodontitis (n = 1052), and 2873 healthy control individuals. The rare G allele of htSNP rs6681231 was associated with aggressive periodontitis prior to and after adjustment for the covariates smoking, diabetes, and gender, with an odds ratio of 1.57 (95% confidence interval 1.18-2.08; p = 0.002). The validation of the association of rs20417 by the htSNP rs6681231 provides evidence for a general genetic risk of COX-2 variants in the pathogenesis of periodontitis.