Impairment of extra-high frequency auditory thresholds in subjects with elevated levels of fasting blood glucose.
Impairment of extra-high frequency auditory thresholds in subjects with elevated levels of fasting blood glucose.
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DOI：
10.1016/j.joto.2017.10.003
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发表时间：
2018-03
影响因子：
1.9
通讯作者：
Akhand AA
中科院分区：
文献类型：
--
作者：
Das A;Sumit AF;Ahsan N;Kato M;Ohgami N;Akhand AA
本研究旨在评估孟加拉国人群中空腹血糖(FBG)升高与听力障碍之间是否存在关联。共有142名受试者(72名空腹血糖升高；70名对照组)纳入研究。对照组1、4、8、12分贝频率的平均听阈分别为6.35±0.35、10.07±0.91、27.57±1.82、51.28±3.01分贝SPL(分贝声压级)，空腹血糖升高组分别为8.33±0.66、14.37±1.14、38.96±2.23、71.11±2.96分贝。在上述所有频率下，空腹血糖升高的受试者的听阈均显著高于对照组受试者(P<0.05)，尽管听力损害在超高频率(12千赫)下最为明显。与糖尿病病程较短的受试者(≤为10年)相比，糖尿病病程较长(10年)的受试者在8和12千赫兹的听阈水平显著较高，但在1和4千赫兹的频率上没有显著升高。此外，根据优势比数据，与各自的对照组相比，年龄较大(>；40岁)和较年轻(≤40岁)的糖尿病受试者在超高频频率下观察到更严重的听力损害。二元Logistic回归分析显示，在调整了年龄、性别和BMI后，糖尿病受试者发生超高频听力障碍的几率增加了5.79倍。这项研究提供了确凿的证据，表明超高频听阈可能是糖尿病受试者听力损害的敏感标志。
This study was performed to assess whether there is an association between elevated Fasting Blood Glucose (FBG) and hearing impairment in Bangladeshi population. A total of 142 subjects (72 with elevated FBG; 70 control) were included in the study. The mean auditory thresholds of the control subjects at 1, 4, 8 and 12 kHz frequencies were 6.35 ± 0.35, 10.07 ± 0.91, 27.57 ± 1.82, 51.28 ± 3.01 dB SPL (decibel sound pressure level), respectively and that of the subjects with elevated FBG were 8.33 ± 0.66, 14.37 ± 1.14, 38.96 ± 2.23, and 71.11 ± 2.96 dB, respectively. The auditory thresholds of the subjects with elevated FBG were significantly (p < 0.05) higher than the control subjects at all the above frequencies, although hearing impairment was most evidently observed at an extra-high (12 kHz) frequency. Subjects with a long duration of diabetes (>10 years) showed significantly (p < 0.05) higher level of auditory thresholds at 8 and 12 kHz, but not at 1 and 4 kHz frequencies, compared to subjects with shorter duration of diabetes (≤10 years). In addition, based on the data of odds ratio, more acute impairment of hearing at the extra-high frequency was observed in diabetic subjects of both older (>40 years) and younger (≤40 years) age groups compared to the respective controls. The binary logistic regression analysis showed a 5.79-fold increase in the odds of extra-high frequency hearing impairment in diabetic subjects after adjustment for age, gender and BMI. This study provides conclusive evidence that auditory threshold at an extra-high frequency could be a sensitive marker for hearing impairment in diabetic subjects.