Chitosan and Fish Collagen as Biomaterials for Regenerative Medicine
Chitosan and Fish Collagen as Biomaterials for Regenerative Medicine
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DOI：
10.1016/b978-0-12-416003-3.00006-8
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Ikeda, Takeshi
中科院分区：
文献类型：
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作者：
Hayashi, Yoshihiko;Yamada, Shizuka;Ikeda, Takeshi
本章重点介绍了壳聚糖和海产品中的胶原蛋白的特性及其在生物医学中的应用，以及再生医学的优缺点。了解壳聚糖和胶原蛋白的生产过程以及这些生物材料的构象对于促进其理论和实践的有效性是不可或缺的。在考虑将壳聚糖作为支架应用于临床之前，需要控制壳聚糖在硬组织和软组织上的初始炎症反应。此外，由于壳聚糖在体内的生物降解时间太长，一般不适合作为退行性药物支架，尤其是牙髓组织。据报道，从热带鱼鳞片中提取的胶原蛋白的降解温度为35℃。鱼胶原蛋白的生物相容性和生物降解性适合作为再生医学的支架。
This chapter focuses and reviews on the characteristics and biomedical application of chitosan and collagen from marine products and advantages and disadvantages of regeneration medicine. The understanding of the production processes of chitosan and collagen and the conformation of these biomaterials are indispensable for promoting the theoretical and practical availability. The initial inflammatory reactions associated with chitosan application to hard and soft tissues need to be controlled before it can be considered for clinical application as scaffold. Further, as chitosan takes too long for biodegradation in vivo, generally it is not suitable for the scaffold for degenerative medicine in especially dental pulp tissue. The collagen extract from the scales of tropical fish has been reported to have a degeneration temperature of 35 degrees C. The properties of biocompatibility and biodegradation of fish atelocollagen are suitable for the scaffold in regenerative medicine.