Trans-chromosomal methylation.
Trans-chromosomal methylation.
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DOI：
10.4161/epi.20820
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发表时间：
2012-08
期刊：
影响因子：
3.7
通讯作者：
Peacock WJ
中科院分区：
文献类型：
--
作者：
Greaves I;Groszmann M;Dennis ES;Peacock WJ
表观基因组在帮助维持和调节所有生物体的细胞功能方面起着至关重要的作用。在同一细胞核中具有不同表观遗传标记的等位基因不单独起作用，而是可以反式相互作用以改变一个或两个等位基因的表观遗传状态。当两个不同的表观基因组在杂交中结合在一起时，这一点尤其明显，导致甲基化组发生数千次改变。这些变化主要涉及一个等位基因的甲基化模式被改变为类似于另一个等位基因的甲基化模式，我们称之为跨染色体甲基化（TCM）和跨染色体去甲基化（TCdM）。这些过程主要由siRNA和RNA指导的DNA甲基化途径调节。从其他例子的trans-allelic相互作用，我们描述了TCM和TCdM的过程和这种变化可能对基因组活性的影响。跨等位基因表观遗传相互作用可能是许多生物系统中常见的现象。
The epigenome plays a vital role in helping to maintain and regulate cell functions in all organisms. Alleles with differing epigenetic marks in the same nucleus do not function in isolation but can interact in trans to modify the epigenetic state of one or both alleles. This is particularly evident when two divergent epigenomes come together in a hybrid resulting in thousands of alterations to the methylome. These changes mainly involve the methylation patterns at one allele being changed to resemble the methylation patterns of the other allele, in processes we have termed trans-chromosomal methylation (TCM) and trans-chromosomal demethylation (TCdM). These processes are primarily modulated by siRNAs and the RNA directed DNA methylation pathway. Drawing from other examples of trans-allelic interactions, we describe the process of TCM and TCdM and the effect such changes can have on genome activity. Trans-allelic epigenetic interactions may be a common occurrence in many biological systems.