Brain transcriptomic profiling in idiopathic and LRRK2-associated Parkinson's disease
Brain transcriptomic profiling in idiopathic and LRRK2-associated Parkinson's disease
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DOI：
10.1016/j.brainres.2012.05.036
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发表时间：
2012-07-23
期刊：
影响因子：
2.9
通讯作者：
Tolosa, Eduard
中科院分区：
文献类型：
--
作者：
Botta-Orfila, Teresa;Sanchez-Pla, Alex;Tolosa, Eduard
LRRK2突变是帕金森病（PD）最常见的遗传原因。我们对特发性PD （IPD）和lrrk2相关PD患者的死后组织蓝斑座进行了全基因组RNA分析。蓝斑座是PD患者的一种组织病理学影响的脑组织。在IPD和lrrk2相关PD中发现的差异表达基因参与了突触传递和神经元投射的基因本体论。此外，IPD组中差异表达的基因与免疫系统相关通路相关。具体来说，这项研究强调了位于染色体6p21.3中属于II类HLA的基因的差异表达。我们的研究结果支持了神经炎症和HLA基因区参与IPD发病机制的潜在作用的假设。未来的研究需要进一步阐明免疫系统相关通路在PD发病中的关系。(C) 2012 Elsevier B.V.版权所有
LRRK2 mutations are the most common genetic cause of Parkinson's disease (PD). We performed a whole-genome RNA profiling of locus coeruleus post-mortem tissue, a histopathologically affected brain tissue in PD, from idiopathic PD (IPD) and LRRK2-associated PD patients. The differentially expressed genes found in IPD and LRRK2-associated PD are involved in the gene ontology terms of synaptic transmission and neuron projection. In addition, differentially expressed genes in the IPD group are associated with immune system related pathways. Specifically, the study performed highlights the presence of differential expression of genes located in the chromosome 6p21.3 belonging to the class II HLA. Our findings support the hypothesis of a potential role of neuroinflammation and the involvement of the HLA genetic area in IPD pathogenesis. Future studies are necessary to shed light on the relation of immune system related pathways in the etiopathogenesis of PD. (C) 2012 Elsevier B.V. All rights reserved.