The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.
复制标题
CD28 和 CTLA4 在 CD4 CD25 调节性 T 细胞的功能和稳态中的作用。
DOI：
10.1002/0470871628.ch5
复制
发表时间：
2003
影响因子：
--
通讯作者：
Bluestone,JeffreyA
中科院分区：
文献类型：
--
作者：
Boden,Elisa;Tang,Qizhi;Bour-Jordan,Helene;Bluestone,JeffreyA
CD4+CD25+T cells regulate a variety of autoimmune and alloimmune responses including the development of autoimmune diabetes in non‐obese diabetic (NOD) mice. We have examined the role of CD28/CTLA4/B7 interactions in the expansion and survival of CD4+CD25+regulatory T cells (Treg) in this setting. CD28/B7 interactions are essential in the development of Tregin the thymus and for their survival in the periphery. The CD28‐mediated homeostasis of these cells is independent of IL2, OX40, CD40L, and survival factor Bcl‐XL. In addition, analysis of Tregfrom CTLA4‐deficient mice suggests that CTLA4 expression is not required for their development or function. However, non‐activating anti‐CTLA4 antibodies blocked the suppressor activity of regulatory cellsin vitro. Thus, clinical application of co‐stimulatory blockade using agents such as CTLA4Ig in the treatment of autoimmune disease may result in complicated outcomes.
