Six-Year Incidence of Age-Related Macular Degeneration in Asian Malays
Six-Year Incidence of Age-Related Macular Degeneration in Asian Malays
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DOI：
10.1016/j.ophtha.2017.03.056
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发表时间：
2017-09-01
期刊：
影响因子：
13.7
通讯作者：
Wong, Tien Yin
中科院分区：
文献类型：
--
作者：
Cheung, Chui Ming Gemmy;Ong, Peng Guan;Wong, Tien Yin
目的：确定新加坡马来人群中早期和晚期年龄相关性黄斑变性（AMD）的6年发病率，并验证亚洲人群中AMD相关眼病研究（AREDS）简化严重程度量表。设计：前瞻性人群队列研究。参与者：新加坡马来人眼科研究基线参与者（年龄，>= 40岁; 2006-2008年）在2011年至2013年进行了随访，3280名合格参与者中有1901名（72.1%）参加了研究。主要结局指标：早期和晚期AMD的发病率。结果：1809名参加基线和6年随访检查的参与者可获得分级眼底照片。早期和晚期AMD的年龄标准化发生率分别为5.89%（95%置信区间[CI]，4.81-7.16）和0.76%（95% CI，0.42-1.29）。与比弗坝眼科研究人群（8.19%）相比，我们人群（5.58%; 95% CI，4.43-7.01）中早期AMD的5年年龄标准化发病率（根据6年发病率计算）较低。我们人群中晚期AMD的发病率与比弗坝眼科研究人群相似（0.98% [95% CI，0.49-1.86] vs. 0.91%），蓝山眼科研究人群（1.10% [95% CI，0.52-9.56] vs. 1.10%）和Hisayama研究人群（1.09% [95% CI，0.54-4.25] vs. 0.84%）。晚期AMD的发病率随着基线AREDS评分的增加而显著增加（0级，0.23%; 4级，9.09%）。结论：本研究记录了马来人群中早期和晚期AMD的发病率。AREDS简化严重程度量表可用于预测亚洲人晚期AMD发展的风险。(C)2017年由美国眼科学会。
Purpose: To determine the 6-year incidence of early and late age-related macular degeneration (AMD) in a Singaporean Malay population and to validate the Age-Related Eye Disease Study (AREDS) simplified severity scale in Asians.Design: Prospective, population cohort study.Participants: The Singapore Malay Eye Study baseline participants (age, >= 40 years; 2006-2008) were followed up in 2011 through 2013, and 1901 of 3280 of eligible participants (72.1%) took part.Methods: Fundus photographs were graded using the Wisconsin AMD grading system. Main Outcome Measures: Incidence of early and late AMD.Results: Gradable fundus photographs were available for 1809 participants who attended both baseline and 6-year follow-up examinations. The age-standardized incidences of early and late AMD were 5.89% (95% confidence interval [CI], 4.81-7.16) and 0.76% (95% CI, 0.42-1.29), respectively. The 5-year age-standardized incidence of early AMD (calculated based on the 6-year incidence) was lower in our population (5.58%; 95% CI, 4.43-7.01) compared with the Beaver Dam Eye Study population (8.19%). The incidence of late AMD in our population was similar to that of the Beaver Dam Eye Study population (0.98% [95% CI, 0.49-1.86] vs. 0.91%), the Blue Mountains Eye Study population (1.10% [95% CI, 0.52-9.56] vs. 1.10%), and the Hisayama Study population (1.09% [95% CI, 0.54-4.25] vs. 0.84%). The incidence of late AMD increased markedly with increasing baseline AREDS score (step 0, 0.23%; step 4, 9.09%).Conclusions: This study documented the incidence of early and late AMD in a Malay population. The AREDS simplified severity scale is useful in predicting the risk of late AMD development in Asians. (C) 2017 by the American Academy of Ophthalmology.