Osteoporosis and risk of fracture in men with spinal cord injury
Osteoporosis and risk of fracture in men with spinal cord injury
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DOI：
10.1038/sj.sc.3101139
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发表时间：
2001-04-01
期刊：
影响因子：
2.2
通讯作者：
Muppidi, M
中科院分区：
文献类型：
--
作者：
Lazo, MG;Shirazi, P;Muppidi, M
研究设计：横断面研究，评估脊髓损伤 (SCI) 后的骨矿物质密度 (BMD) 和骨折史。目的：确定 SCI 后骨质疏松和骨折的频率，将骨质流失的程度与 SCI 后骨折的频率相关联，并确定 SCI 患者的骨折风险。地点：美国伊利诺伊州海因斯退伍军人事务医院。方法：测量了 41 名有创伤性或缺血性 SCI 病史的个体的股骨颈 BMD使用双能X射线骨密度仪（DEXA月球全身密度计模型）。结果：25名患者（61％）符合世界卫生组织（WHO）骨质疏松症标准，8名（19.5％）骨质减少，8名（19.5％）正常。 14 名患者 (34%) 发生 SCI 后骨折。有骨折史的患者与无骨折史的患者相比，股骨颈 BMD 和 SCI 持续时间存在显着差异。对于同一年龄组的患者，股骨颈BMD每减少0.1 gm/cm(2)和标准差(SD)(t值)每减少一个单位，骨折风险分别增加2.2和2.8倍。与年龄、SCI 持续时间和 SCI 级别同时考虑，BMD 是骨折数量的唯一显着预测因子。结论：SCI 后会发生骨质疏松症和骨折频率增加。股骨颈 BMD 的测量可用于量化 SCI 患者的骨折风险。
Study design: Cross-sectional study to evaluate bone mineral density (BMD) and fracture history after spinal cord injury (SCI).Objectives: To determine frequency of osteoporosis and fractures after SCI, correlate extent of bone loss with frequency of fractures after SCI, and determine fracture risk in SCI patients.Setting: The Hines Veterans Affairs Hospital in Hines, Illinois, USA.Methods: Femoral neck BMD was measured in 41 individuals with a history of traumatic or ischemic SCI using dual-energy X-ray absorptiometry (DEXA Lunar Whole Body Densitometer Model).Results: Twenty-five patients (61%) met the World Health Organization (WHO) criteria for osteoporosis, eight (19.5%) were osteopenic, and eight (19.5%) were normal. Fracture after SCI had occurred in 14 patients (34%). There were significant differences between the femoral neck BMD and SCI duration in patients with a fracture history compared to those without. For patients in the same age group, each 0.1 gm/cm(2) and each unit of standard deviation (SD) (t-value) decrement of BMD at the femoral neck increased the risk of fracture 2.2 and 2.8 times, respectively. Considered simultaneously with age, duration of SCI, and level of SCI, BMD was the only significant predictor of the number of fractures.Conclusion: Osteoporosis and an increased frequency of fractures occur after SCI. Measurement of femoral neck BMD can be used to quantify fracture risk in SCI patients.