Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma
Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma
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DOI：
10.1158/0008-5472.can-10-0352
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发表时间：
2010-12-01
期刊：
影响因子：
11.2
通讯作者：
Feltkamp, Mariet C. W.
中科院分区：
文献类型：
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作者：
Bavinck, Jan Nico Bouwes;Neale, Rachel E.;Feltkamp, Mariet C. W.
由于信息匮乏，β属的人乳头瘤病毒 (betaPV) 无法根据其致癌性进行分类。本研究结合紫外线暴露和敏感性测量评估了 betaPV 感染与皮肤鳞状细胞癌之间的关联。我们在荷兰、意大利和澳大利亚这些紫外线暴露程度截然不同的国家进行了病例对照研究。使用高度敏感的 HPV DNA 基因分型测定确定眉毛毛囊中是否存在 25 种 betaPV 类型，并使用多重血清学检测了总共 689 例鳞状细胞癌病例和 845 例对照中 15 种最常见的 betaPV 类型的抗体。多变量逻辑回归模型用于病例对照比较和交互分析。超过 90% 的参与者的眉毛中检测到了 BetaPV DNA。在荷兰（OR 2.8；95% CI 1.3-5.8）和意大利（OR 1.7；95% CI 0.79-3.6），βPV DNA 的存在与鳞状细胞癌风险增加相关，但在澳大利亚则不然（OR 0.91；95% CI 0.53-1.6）。对照中 betaPV 的血清阳性率为 52% 至 67%。针对 4 种或更多 betaPV 类型的阳性抗体反应与澳大利亚（OR 2.2；95% CI 1.4-3.3）、荷兰（OR 2.0；95% CI 1.2-3.4）和白皮肤意大利人（OR 1.6，95% CI 0.94-2.7）的鳞状细胞癌相关。在 betaPV 血清阳性人群中，紫外线敏感性与鳞状细胞癌之间的相关性更强。这些综合数据支持这样的假设：betaPV 可能在皮肤鳞状细胞癌的发展中发挥作用。癌症研究； 70(23)； 9777-86。 (C)2010 AACR。
Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.