Oxidation of amines by flavoproteins.

Oxidation of amines by flavoproteins.
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DOI:
10.1016/j.abb.2009.07.019
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发表时间:
2010-01-01
影响因子:
3.9
通讯作者:
Fitzpatrick PF
Fitzpatrick PF
中科院分区:
生物学3区
文献类型:
--
作者:
Fitzpatrick PF

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许多黄素蛋白催化伯胺和仲胺的氧化,将氢化物等价物从碳-氮键转移到黄素辅因子。这些胺氧化酶中的大多数可以分为两个结构家族,D -氨基酸氧化酶/肌氨酸氧化酶家族和单胺氧化酶家族。本文综述了目前对黄素蛋白氧化胺和氨基酸的机制的认识,重点是这两个结构家族。
Many flavoproteins catalyze the oxidation of primary and secondary amines, with the transfer of a hydride equivalent from a carbon -nitrogen bond to the flavin cofactor. Most of these amine oxidases can be classified into two structural families, the D -amino acid oxidase/sarcosine oxidase family and the monoamine oxidase family. This review discusses the present understanding of the mechanisms of amine and amino acid oxidation by flavoproteins, focusing on these two structural families.
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发表时间: 1995-03-21
期刊: BIOCHEMISTRY
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