A comparison of fluvoxamine and fluoxetine in the treatment of major depression.
A comparison of fluvoxamine and fluoxetine in the treatment of major depression.
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氟伏沙明和氟西汀治疗重度抑郁症的比较。
DOI：
10.1097/00004714-199610000-00005
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发表时间：
1996
影响因子：
2.9
通讯作者：
Bradford,D
中科院分区：
文献类型：
--
作者：
Rapaport,M;Coccaro,E;Sheline,Y;Perse,T;Holland,P;Fabre,L;Bradford,D
这项针对100名严重抑郁症门诊患者的随机、双盲、平行分组研究是美国第一项比较氟伏沙明(100-150毫克/天)和氟西汀(20-80毫克/天)的疗效和耐受性的研究。经过可变的单盲洗脱期后，患者被随机分成两组，分别接受氟伏沙明(51例)和氟西汀(49例)治疗7周。采用汉密尔顿抑郁量表(HAM-D)和临床总体印象量表(HAM-D)评估疗效。每个治疗组中84%的人完成了研究，每组在结束时的平均得分都低于10。在为期7周的试验中，两组的HAM-D得分都有60%的改善。两组之间在任何疗效参数上都没有观察到显著的统计学差异。这些药物的耐受性很好，每组只有两名患者因副作用而终止治疗。副作用情况有所不同，与氟西汀相比，氟伏沙明的恶心程度更低。总而言之，氟伏沙明和氟西汀在减轻抑郁症状方面同样有效，但两种药物表现出略有不同的副作用(J临床精神药理学杂志1996；16：373-378)。
This randomized, double-blind, parallel-group design study of 100 outpatients with major depressive disorder is the first study in the United States to compare the efficacy and tolerability of fluvoxamine (100-150 mg/day) and fluoxetine (20-80 mg/day). After a variable, single-blind, washout period, patients were randomized to receive either fluvoxamine (51 patients) of fluoxetine (49 patients) for 7 weeks. Efficacy was assessed with the 21-item Hamilton Rating Scale for Depression (HAM-D), and Clinical Global Impressions scale for severity and improvement. Eighty-four percent of each treatment group completed the study with each group having a mean score at end point of less than 10. Both groups demonstrated a 60% improvement in HAM-D scores over the 7-week trial. There were no statistically significant differences observed between the two groups on any efficacy parameter. The medications were well tolerated, with only two patients in each group who were terminated because of side effects. There were differences in the side-effect profiles, with fluvoxamine being associated with less nausea than fluoxetine. In summary, fluvoxamine and fluoxetine were equally effective in reducing depressive symptoms, but the two drugs displayed slightly different side-effect profiles.(J Clin Psychopharmacol 1996; 16: 373-378).
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DOI：
--
发表时间：
1981
期刊：
影响因子：
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作者：
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作者：
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Wernicke Jf