Mixed ductal-endocrine carcinomas of the pancreas and ductal adenocarcinomas with scattered endocrine cells: characterization of the endocrine cells
Mixed ductal-endocrine carcinomas of the pancreas and ductal adenocarcinomas with scattered endocrine cells: characterization of the endocrine cells
复制标题
胰腺混合性导管内分泌癌和具有分散内分泌细胞的导管腺癌：内分泌细胞的特征
作者：
Nobuyuki Ohike;A. Jürgensen;M. Pipeleers‐Marichal;G. Klöppel
我们比较了胰腺混合性导管内分泌癌与含有分散的肿瘤相关内分泌细胞（SEC）的导管腺癌（DAC）的组织学和免疫组织化学特征。三种胰腺肿瘤符合世界卫生组织混合导管内分泌癌的标准。其中两个显示出中度至低分化的腺体结构，由粘蛋白产生细胞和神经内分泌细胞组成。第三种混合性导管内分泌癌是复合型，显示 DAC 结构和带有小上皮细胞的实性成分，其中大多数具有神经内分泌性质。 34例位于胰头（30例）、胰体尾部（4例）且有淋巴结转移的DAC中，有32例发现SEC，但数量较少且分布不规则。在三个 DAC 中，在淋巴结转移中也检测到了一些 SEC。嗜铬粒蛋白 A 和增殖标记物 Ki-S5 的双重染色显示，所有未紧密整合到肿瘤腺上皮中的 SEC 均未表现出增殖活性和抑癌基因（p53 和 DPC 4）表达的变化。这些发现表明，只有那些属于增殖细胞部分的 SEC 可能具有肿瘤起源，而大多数 SEC 可能构成肿瘤相关但非肿瘤细胞群。这些特征与混合性导管内分泌癌形成鲜明对比，混合性导管内分泌癌中所有内分泌细胞都是肿瘤的组成部分。
We compared the histological and immunohistochemical features of mixed ductal-endocrine carcinomas of the pancreas with those of ductal adenocarcinomas (DACs) containing scattered tumor-associated endocrine cells (SECs). Three pancreatic neoplasms fulfilled the WHO criteria for mixed ductal-endocrine carcinomas. Two of them showed moderately to poorly differentiated glandular structures composed of both mucin producing and neuroendocrine cells. The third mixed ductal-endocrine carcinoma was of the composite type showing DAC structures and a solid component with small epithelial cells, most of them of neuroendocrine nature. In 32 of 34 cases of DAC located in the head (30 cases) and body to tail (4 cases) of the pancreas and showing lymph-node metastases, SECs were found, but they were few in number and irregularly distributed in the tumors. In three DACs a few SECs were also detected in lymph-node metastases. Double staining for chromogranin A and the proliferation marker Ki-S5 revealed that all SECs that were not intimately integrated into the neoplastic glandular epithelium failed to show proliferative activity and changes of the expression of tumor suppressor genes (p53 and DPC 4). These findings suggest that only those SECs that belong to the proliferative cell fraction may be of neoplastic origin, while the majority of SECs probably constitute a tumor-associated but non-neoplastic cell population. These features contrast with those of mixed ductal-endocrine carcinomas, in which all endocrine cells are a component of the neoplasm.
影响因子：
158.5
作者：
PERMERT, J;LARSSON, J;ADRIAN, TE
通讯作者：
ADRIAN, TE