Dynamic Contrast-Enhanced Ultrasound Modeling of an Analog to Pseudo-Diffusivity in Intravoxel Incoherent Motion Magnetic Resonance Imaging.
Dynamic Contrast-Enhanced Ultrasound Modeling of an Analog to Pseudo-Diffusivity in Intravoxel Incoherent Motion Magnetic Resonance Imaging.
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DOI：
10.1109/tmi.2022.3197363
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发表时间：
2022-12
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
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作者：
肿瘤灌注和血管特性是癌症对治疗反应的重要决定因素，因此正在探索各种成像灌注方法。特别是，体素内不相干运动 (IVIM) MRI 作为动态对比增强 (DCE) CT 和 DCE-MRI 的替代方案正在积极研究，因为它提供非电离、非对比灌注成像。然而，对于短时间内的重复治疗评估，IVIM MRI 的缺点仍然是成本高、访问受限以及无法在床边扫描。我们提出了一种分析框架，可以实现 3D DCE 超声 (DCE-US)——低成本、具有良好安全记录的床边成像——作为 IVIM MRI 的替代方式，用于在声学可及的解剖结构和肿瘤中生成基于 DCE-US 的伪扩散率图。将血管内对比传播建模为对流扩散过程，我们通过解决大规模全耦合逆问题来重建伪扩散率的参数图，而不对重建参数的局部恒定性做出任何假设。在小鼠肿瘤模型中，我们证明 3D DCE-US 伪扩散率是可重复的，对抗血管生成剂治疗敏感，并且与灌注和血管生成的组织学测量适度相关。
Tumor perfusion and vascular properties are important determinants of cancer response to therapy and thus various approaches for imaging perfusion are being explored. In particular, Intravoxel Incoherent Motion (IVIM) MRI has been actively researched as an alternative to Dynamic-Contrast-Enhanced (DCE) CT and DCE-MRI as it offers non-ionizing, non-contrast-based perfusion imaging. However, for repetitive treatment assessment in a short time period, high cost, limited access, and inability to scan at the bedside remain disadvantages of IVIM MRI. We propose an analysis framework that may enable 3D DCE Ultrasound (DCE-US) - low cost, bedside imaging with excellent safety record - as an alternative modality to IVIM MRI for the generation of DCE-US based pseudo-diffusivity maps in acoustically accessible anatomy and tumors. Modelling intravascular contrast propagation as a convective-diffusive process, we reconstruct parametric maps of pseudo-diffusivity by solving a large-scale fully coupled inverse problem without any assumptions regarding local constancy of the reconstructed parameters. In a mouse tumor model, we demonstrate that the 3D DCE-US pseudo-diffusivity is repeatable, sensitive to treatment with an antiangiogenic agent, and moderately correlated to histological measures of perfusion and angiogenesis.
DOI：
10.1186/s13014-021-01747-z
发表时间：
2021-01-13
期刊：
Radiation oncology (London, England)
影响因子：
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作者：
Yang DM;Palma DA;Kwan K;Louie AV;Malthaner R;Fortin D;Rodrigues GB;Yaremko BP;Laba J;Gaede S;Warner A;Inculet R;Lee TY
通讯作者：
Lee TY