Vitamin and Mineral Status in Patients With Inflammatory Bowel Disease
Vitamin and Mineral Status in Patients With Inflammatory Bowel Disease
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DOI：
10.1097/mpg.0b013e31826a105d
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发表时间：
2013-01-01
影响因子：
2.9
通讯作者：
Baker, Susan S.
中科院分区：
文献类型：
--
作者：
Alkhouri, Razan H.;Hashmi, Humaira;Baker, Susan S.
目的：炎症性肠病（IBD）患者存在维生素和矿物质缺乏的风险，因为肠道粘膜长期炎症和口服摄入量减少。本研究的目的是调查新诊断的IBD患者与对照组相比，维生素和锌缺乏症的患病率。方法：这是一个回顾性的图表审查所有诊断为IBD的患者从2006年至2010年，年龄1至18岁。在诊断时获得脂溶性和水溶性维生素（A、E、D 25-OH、叶酸和B-12）和锌水平的患者纳入研究。共61例IBD患者和61名年龄和性别匹配的对照者被包括在内。结果：61例IBD患者中没有叶酸或维生素B12缺乏。62%的患者发现维生素D缺乏，16%的患者发现维生素A缺乏，5%的患者发现维生素E缺乏，40%的患者发现锌缺乏。对照组有75%，8%，和19%patients.Conclusions的维生素D和E和锌缺乏症：我们得出结论，维生素B12和叶酸缺乏症是罕见的，在美国新诊断的IBD儿童，我们的问题是否例行监测是必要的。维生素A和锌缺乏在新诊断的IBD患者中很常见，应在诊断时评估水平，以便开始肠内充盈。维生素D缺乏症在纽约州布法罗地区的所有儿童中很常见，因此有必要对这种缺乏症进行常规筛查。
Objectives: Patients with inflammatory bowel disease (IBD) are at risk for vitamin and mineral deficiencies because of long-term inflammation in the gut mucosa and decreased oral intake. The aim of the study is to investigate the prevalence of vitamin and zinc deficiencies in patients with newly diagnosed IBD compared with a control group.Methods: This is a retrospective chart review of all of the patients diagnosed as having IBD from 2006 to 2010, ages 1 to 18 years. Patients who had fat- and water-soluble vitamins (A, E, D 25-OH, folate, and B-12) and zinc levels obtained at time of diagnosis were included in the study. A total of 61 patients with IBD and 61 age- and sex-matched controls were included.Results: None of the 61 patients with IBD had folate or vitamin B12 deficiency. Vitamin D deficiency was found in 62% of the patients, vitamin A deficiency in 16%, vitamin E deficiency in 5%, and zinc deficiency in 40%. The control group had vitamin D and E and zinc deficiency in 75%, 8%, and 19% patients, respectively.Conclusions: We conclude that vitamin B12 and folate deficiencies are rare in children with newly diagnosed IBD in the United States and we question whether routine monitoring is warranted. Vitamin A and zinc deficiency are common in patients with newly diagnosed IBD and levels should be assessed at the time of diagnosis so that enteral repletion can commence. Vitamin D deficiency is common in all of the children in the Buffalo, NY, area, and routine screening for this deficiency is warranted.