Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update.
Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update.
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发表时间：
2010-04
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通讯作者：
Jianming Lü;J. Nurko;Sarah M. Weakley;Jun Jiang;P. Kougias;P. Lin;Q. Yao;Changyi J. Chen
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作者：
Jianming Lü;J. Nurko;Sarah M. Weakley;Jun Jiang;P. Kougias;P. Lin;Q. Yao;Changyi J. Chen
木酚灌木，Larrea tridentata，在美国被称为chaparral或greasewood，在墨西哥被称为gobernadora或hediondilla。北二氢愈创木酸（NDGA）是木酚油灌木的主要代谢物，已被证明在治疗多种疾病，包括心血管疾病、神经系统疾病和癌症方面具有前景。杂酚油灌木是一种很有前途的北美草药制剂，具有广泛的药理作用和特定的作用机制。本文综述了NDGA体外和体内研究的最新进展，并介绍了NDGA作为抗氧化剂的实验研究。此外，基于NDGA对心血管、免疫和神经系统影响的潜在医疗用途；癌症;组织工程;并讨论了药代动力学和毒性。
Creosote bush, Larrea tridentata, is known as chaparral or greasewood in the United States and as gobernadora or hediondilla in Mexico. Nordihydroguaiaretic acid (NDGA), the main metabolite of the creosote bush, has been shown to have promising applications in the treatment of multiple diseases, including cardiovascular diseases, neurological disorders and cancers. Creosote bush is a promising agent of North American herbal medicine, and it has extensive pharmacological effects and specific mechanisms of actions. This review provides an update of recent in vitro and in vivo research about NDGA and describes experimental studies using NDGA as antioxidant. Also, potential medical uses based on the effects of NDGA on the cardiovascular, immune and neurological systems; cancer; tissue engineering; as well as pharmacokinetics and toxicity are discussed.