Management guideline for Werner syndrome 2020. 7. Skin ulcer associated with Werner syndrome: Dermatological treatment
Management guideline for Werner syndrome 2020. 7. Skin ulcer associated with Werner syndrome: Dermatological treatment
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2020年沃纳综合征管理指南。7.与沃纳综合征相关的皮肤溃疡：皮肤科治疗
DOI：
10.1111/ggi.14077
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发表时间：
2020
影响因子：
3.3
通讯作者：
Yokote Koutaro
中科院分区：
文献类型：
--
作者：
Motegi Sei‐ichiro;Takemoto Minoru;Taniguchi Toshibumi;Kubota Yoshitaka;Taniguchi Akira;Nakagami Hironori;Maezawa Yoshiro;Koshizaka Masaya;Kato Hisaya;Mori Seijiro;Tsukamoto Kazuhisa;Kuzuya Masafumi;Yokote Koutaro
Werner综合征中的皮肤溃疡通常由过度角化病变和压力点（如足底区域）的创伤引起，并且比健康个体中的伤口愈合更难治疗。多种因素导致Werner综合征的顽固性皮肤溃疡，包括皮肤变薄、硬化、脂肪组织损失、血流受损、钙化和骨关节畸形导致的过度压力。治疗包括局部应用角化溶解剂治疗溃疡周围的角化病。溃疡的治疗与正常溃疡相同，如果溃疡与感染和坏死组织有关，应尽可能在用盐水或温和的温水或抗菌剂冲洗后用手术刀或剪刀进行手术清创。局部用药，促进软化和清创的坏死组织使用小心控制水分在伤口。促进肉芽形成的局部药物应用于坏死组织已被清除而无感染的伤口。维持伤口湿润环境的敷料也可能是有用的。如果保守治疗伤口没有改善，应考虑手术治疗。Geriatr Gerontol Int 2021; 21：160-162。
Skin ulcers in Werner's syndrome often arise from hyperkeratotic lesions and trauma to pressure points such as the plantar region, and are more difficult to treat than wound healing in healthy individuals. Multiple factors contribute to the intractable skin ulcers in Werner's syndrome, including skin thinning, sclerosis, fatty tissue loss, impaired blood flow, calcification, and excessive pressure due to osteoarticular deformity. Treatment includes topical application of a keratolytic agent for keratosis around the ulcer. Treatment of ulcers is the same as for normal ulcers, and if the ulcer is associated with infection and necrotic tissue, surgical debridement with a scalpel or scissors should be performed as much as possible after washing with saline or mildly warm water or with an antibacterial agent. Topical medications that promote softening and debridement of the necrotic tissue are used with careful control of moisture in the wound. Topical agents that promote granulation should be used in wounds where necrotic tissue has been removed without infection. Dressings to maintain a moist environment in the wound may also be useful. If the wound does not improve with conservative treatment, surgical treatment should be considered.Geriatr Gerontol Int 2021; 21: 160–162.
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DOI：
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发表时间：
1998
期刊：
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影响因子：
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