Causes and consequences of the gender difference in age at onset of schizophrenia
Causes and consequences of the gender difference in age at onset of schizophrenia
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DOI：
10.1093/oxfordjournals.schbul.a033317
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发表时间：
1998-01-01
影响因子：
6.6
通讯作者：
Stein, A
中科院分区：
文献类型：
--
作者：
Häfner, H;an der Heiden, W;Stein, A
ABC（年龄、开始、病程）精神分裂症研究始于 1987 年，旨在生成和检验有关精神分裂症致病因素的假设，该研究的主要分支之一侧重于性别如何影响精神分裂症的发病年龄分布、症状学、疾病行为和早期病程，从一项罕见的、显着偏差、一致的发现——首次入院年龄的性别差异——出发，我们发起了这项研究。 通过在一系列子研究中生成和检验假设来系统地寻找解释。我们从流行病学转向神经生物学，最后转向临床水平。本文试图简要概述 ABC 研究的各个阶段以及在动物实验中制定和检验雌激素假说以及证明其对人类精神分裂症的适用性所涉及的不同调查水平。根据这些结果，我们提出了三个假设，并根据 ABC 研究 232 例首发精神分裂症病例的数据进行了测试。此处描述的分析代表了 ABC 研究的最新阶段。
The ABC (age, beginning, course) schizophrenia study was commenced in 1987 to generate and test hypotheses about pathogenic aspects of schizophrenia, One of the main branches of the study focused on how gender influences the age distribution of onset, symptomatology, illness behavior, and early course in schizophrenia, Proceeding from one of the rare, strikingly deviating, consistent findings-the gender difference in age at first admission-we launched a systematic search for explanations by generating and testing hypotheses in a series of substudies. We moved from the epidemiological to the neurobiological and finally to the clinical level, The present article is an attempt to provide a brief overview of the individual stages of the ABC study and the different levels of investigation involved in formulating and testing the estrogen hypothesis in animal experiments and in demonstrating its applicability to human schizophrenia. From these results, three hypotheses were formulated and tested on data from an ABC study sample of 232 first-episode cases of schizophrenia, The analyses described here represent the latest stages of the ABC study.