DNA-templated coinage metal nanostructures and their applications in bioanalysis and biomedicine
DNA-templated coinage metal nanostructures and their applications in bioanalysis and biomedicine
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DOI：
10.1016/j.ccr.2021.214381
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发表时间：
2022-03
影响因子：
20.6
通讯作者：
Shenshan Zhan;Jiajun Jiang;Zhanghua Zeng;Yan Wang;H. Cui
中科院分区：
文献类型：
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作者：
Shenshan Zhan;Jiajun Jiang;Zhanghua Zeng;Yan Wang;H. Cui
众所周知，金属阳离子与DNA碱基之间的配位相互作用为制造广泛的DNA模板金属纳米结构（CMNs）提供了可能性。这些CMNs具有良好的光学、电子、磁性和催化性能，在许多领域得到了广泛的应用。本文首先综述了利用不同DNA模板合成各种类型CMNs的情况，然后讨论了近年来这些纳米结构在生物分析和生物医学中的应用，包括离子检测、核酸检测、酶检测、生物分子检测和生物成像。综述了这些基于dna模板的CMNs的基本工作原理、主要性能特点以及与其他方法相比的优势。最后，提出了该领域有待解决的问题和未来发展的展望。希望本文综述能够揭示dna模板CMNs在生物分析和生物医学领域的广泛应用，并启发更多基于dna模板CMNs的新颖和实用的应用。
The well-known coordination interactions between coinage metal cations and DNA bases provide the possibility of fabricating a broad range of DNA-templated coinage metal nanostructures (CMNs). These CMNs possess useful optical, electronic, magnetic, and catalytic characteristics and have been widely applied in many fields. This review first summarizes the synthesis of CMNs of various types using different DNA templates and then discusses the application of these nanostructures in bioanalysis and biomedicine, including ion detection, nucleic acid detection, enzyme detection, biomolecule detection, and bioimaging in recent years. The basic operational principles, the main performance characteristics, as well as the advantages compared to other methods of these DNA-templated CMNs based applications are reviewed. Finally, the problems that remain to be solved and the prospects for future development in this area are proposed. It is hoped that this review will convey how developments in DNA-templated CMNs have led to numerous applications of them in the bioanalysis and biomedicine fields, and inspire more novel and practical DNA-templated CMNs based applications.