Taxanes and taxoids of the genus Taxus - A comprehensive inventory of chemical diversity.
Taxanes and taxoids of the genus Taxus - A comprehensive inventory of chemical diversity.
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taxus属的紫杉虫和税类 - 化学多样性的综合清单。
DOI：
10.1016/j.phytochem.2021.112829
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发表时间：
2021-10
期刊：
影响因子：
3.8
通讯作者：
Conner CF
中科院分区：
文献类型：
--
作者：
Lange BM;Conner CF
假生物碱二萜紫杉醇®(紫杉醇)在20世纪90年代中期成为一种畅销的抗癌药物。该化合物吸引了相当大的兴趣，因为它的独特机制，稳定微管，从而降低动力性，并最终促进有丝分裂停止。紫杉醇最初是从红豆杉属植物中分离出来的。在过去的50年里，从不同的红豆杉属植物中分离出了近600种紫杉烷骨架代谢物，并报道了它们的结构。本文综述了紫杉烷的已知化学多样性，重点介绍了二萜类支架的官能化。紫杉烷代谢产物的化学多样性对于紫杉醇生物合成的解体和途径工程的实现也进行了讨论。
The pseudoalkaloid diterpene Taxol® (paclitaxel) emerged as a best-selling anti-cancer drug in the mid-1990s. The compound attracted considerable interest because of its unique mechanism to stabilize microtubules, thus reducing dynamicity and ultimately promoting mitotic arrest. Taxol was originally isolated from members of the genus Taxus. Over the last 50 years, close to 600 metabolites with taxane scaffolds were isolated from various Taxus species and their structures reported. The present review article provides an overview of the known chemical diversity of taxanes, with an emphasis on the functionalization of diterpene scaffolds. The implications of the occurrence of chemically diverse taxane metabolites for unraveling Taxol biosynthesis and enabling pathway engineering are discussed as well.
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影响因子：
5.1
作者：
APPENDINO, G;TAGLIAPIETRA, S;BOMBARDELLI, E
通讯作者：
BOMBARDELLI, E
影响因子：
3.8
作者：
BALZA, F;TACHIBANA, S;TOWERS, GHN
通讯作者：
TOWERS, GHN
影响因子：
5.1
作者：
Banskota, AH;Usia, T;Kadota, S
通讯作者：
Kadota, S
影响因子：
3.8
作者：
BARBONI, L;GARIBOLDI, P;BOMBARDELLI, E
通讯作者：
BOMBARDELLI, E
影响因子：
5.1
作者：
Ando, M;Sakai, J;Hagiwara, H
通讯作者：
Hagiwara, H