Exploring fungal RiPPs from the perspective of chemical ecology.
Exploring fungal RiPPs from the perspective of chemical ecology.
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DOI：
10.1186/s40694-022-00144-9
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发表时间：
2022-06-25
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自2007年首次发现真菌核糖体合成和后修饰肽（RIPPs）以来，这组天然产物经历了快速扩张，现在有四个独立的类别：鹅膏毒素/鬼笔毒素，borosins，dikaritins和epichloëcyclins。大多数情况下，由于它们在医学和农业中的历史上以生物为中心的就业，很少研究与真菌本身相关的新真菌蛋白质和肽。因此，尽管这些化合物赋予人类的好处经常被意识到，但它们对真菌的进化优势，它们持续生产的原因，往往是模糊的或被忽视的。本文综述了这些小肽衍生产品如何影响其生产物种和周围生物环境的现有知识。
Since the initial detection, in 2007, of fungal ribosomally synthesised and post-translationally modified peptides (RiPPs), this group of natural products has undergone rapid expansion, with four separate classes now recognised: amatoxins/phallotoxins, borosins, dikaritins, and epichloëcyclins. Largely due to their historically anthropocentric employment in medicine and agriculture, novel fungal proteins and peptides are seldom investigated in relation to the fungus itself. Therefore, although the benefits these compounds confer to humans are often realised, their evolutionary advantage to the fungus, the reason for their continued production, is often obscure or ignored. This review sets out to summarise current knowledge on how these small peptide-derived products influence their producing species and surrounding biotic environment.