Hostile marital interactions, proinflammatory cytokine production, and wound healing
Hostile marital interactions, proinflammatory cytokine production, and wound healing
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DOI：
10.1001/archpsyc.62.12.1377
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发表时间：
2005-12-01
影响因子：
--
通讯作者：
Glaser, R
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser, JK;Loving, TJ;Glaser, R
背景：越来越多的流行病学文献表明，婚姻不和是发病率和死亡率的一个危险因素。此外，抑郁症和压力与增强生产的促炎细胞因子，影响频谱的条件与aging.Objective：为了评估敌对的婚姻行为如何调节伤口愈合，以及局部和全身的促炎细胞因子production.Design和Setting：夫妇入院两次到医院的研究单位24小时的交叉试验。研究单位出院后每天评估伤口愈合情况。参与者：42对健康已婚夫妇的志愿者样本，年龄22 - 77岁（平均值[SD]，37.04 [13.05]），已婚平均值（SD）为12.55（11.01）岁。在第一个研究单元的入院过程中，夫妻进行了结构化的社会支持互动，在第二个研究单元的入院过程中，他们讨论了婚姻分歧。夫妇的人际交往行为，伤口愈合，局部和全身的促炎细胞因子的变化进行了评估，在每个研究单位admission.Results：夫妇的水泡伤口愈合更慢，局部细胞因子的产生（IL-6，肿瘤坏死因子α，IL-1 β）是较低的伤口部位后，婚姻冲突比社会支持的相互作用。在两次互动中表现出持续更高水平敌意行为的夫妇的愈合率为低敌意夫妇的60%。高敌对的夫妇也产生了相对较大的增加，血浆IL-6和肿瘤坏死因子a值的冲突后的早晨比后的社会支持的相互作用相比，低敌对coupes.Conclusions：这些数据提供了进一步的机械证据伤口愈合的敏感性，每天的压力。此外，促炎细胞因子水平的更频繁和放大的增加可能会加速一系列与年龄相关的疾病。因此，这些数据也提供了一个窗口，通过敌对或摩擦关系影响生理功能和健康的途径。
Context: A growing epidemiological literature has suggested that marital discord is a risk factor for morbidity and mortality. In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging.Objective: To assess how hostile marital behaviors modulate wound healing, as well as local and systemic proinflammatory cytokine production.Design and Setting: Couples were admitted twice to a hospital research unit for 24 hours in a crossover trial. Wound healing was assessed daily following research unit discharge.Participants: Volunteer sample of 42 healthy married couples, aged 22 to 77 years (mean [SD], 37.04 [13.05]), married a mean (SD) of 12.55 (11.01) years.Interventions: During the first research unit admission, couples had a structured social support interaction, and during the second admission, they discussed a marital disagreement.Main Outcome Measures: Couples' interpersonal behavior, wound healing, and local and systemic changes in proinflammatory cytokine production were assessed during each research unit admission.Results: Couples' blister wounds healed more slowly and local cytokine production (IL-6, tumor necrosis factor alpha, and IL-1 beta) was lower at wound sites following marital conflicts than after social support interactions. Couples who demonstrated consistently higher levels of hostile behaviors across both their interactions healed at 60% of the rate of low-hostile couples. High-hostile couples also produced relatively larger increases in plasma IL-6 and tumor necrosis factor a values the morning after a conflict than after a social support interaction compared with low-hostile couples.Conclusions: These data provide further mechanistic evidence of the sensitivity of wound healing to everyday stressors. Moreover, more frequent and amplified increases in proinflammatory cytokine levels could accelerate a range of age-related diseases. Thus, these data also provide a window on the pathways through which hostile or abrasive relationships affect physiological functioning and health.