Metabolic Alterations at the Crossroad of Aging and Oncogenesis.
Metabolic Alterations at the Crossroad of Aging and Oncogenesis.
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DOI：
10.1016/bs.ircmb.2017.01.003
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发表时间：
2017
影响因子：
--
通讯作者：
Longo V
中科院分区：
文献类型：
--
作者：
Raffaghello L;Longo V
衰老是癌症的主要危险因素。癌症和衰老的特征是类似的代谢失调，包括糖酵解的上调和氧化磷酸化的下调。在这方面，代谢干预可以被视为促进长寿和预防或延缓包括癌症在内的与年龄相关的疾病的有前途的策略。在这篇综述中，我们讨论了最有前途的代谢方法，包括长期热量限制、定期禁食/模仿禁食饮食以及模仿热量限制的药物干预措施。代谢干预也可以被视为与标准癌症治疗（化疗药物、电离辐射和具有特定分子靶标的药物）相结合的辅助抗癌策略，其主要限制因素是对健康细胞的毒性，但也限制了肿瘤细胞容易规避的疗效。事实上，传统的癌症治疗无法区分正常细胞和癌细胞，因此会引起毒副作用，包括继发性恶性肿瘤、心血管和呼吸系统并发症、内分泌疾病和其他慢性疾病，这些疾病类似于甚至在某些情况下会加速与年龄相关的疾病，并深刻影响生活质量。在这种情况下，老年科学有助于理解保护正常细胞免受细胞毒性剂侵害的机制，并找到专注于保护健康细胞同时增强针对恶性细胞的治疗功效的策略。
Aging represents the major risk factor for cancer. Cancer and aging are characterized by a similar dysregulated metabolism consisting in upregulation of glycolysis and downmodulation of oxidative phosphorylation. In this respect, metabolic interventions can be viewed as promising strategies to promote longevity and to prevent or delay age-related disorders including cancer. In this review, we discuss the most promising metabolic approaches including chronic calorie restriction, periodic fasting/fasting-mimicking diets, and pharmacological interventions mimicking calorie restriction. Metabolic interventions can also be viewed as adjuvant anticancer strategies to be combined to standard cancer therapy (chemotherapeutic agents, ionizing radiation, and drugs with specific molecular target), whose major limiting factors are represented by toxicity against healthy cells but also limited efficacy easily circumvented by tumor cells. In fact, conventional cancer therapy is unable to distinguish normal and cancerous cells and thus causes toxic side effects including secondary malignancies, cardiovascular and respiratory complications, endocrinopathies, and other chronic conditions, that resemble and, in some cases, accelerate the age-related disorders and profoundly affect the quality of life. In this scenario, geroscience contributes to the understanding of the mechanisms of protection of normal cells against a cytotoxic agent and finding strategies focused on the preserving healthy cells while enhancing the efficacy of the treatment against malignant cells.
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影响因子：
--
作者：
Caffa, Irene;D'Agostino, Vito;Nencioni, Alessio
通讯作者：
Nencioni, Alessio
影响因子：
29
作者：
Brandhorst S;Choi IY;Wei M;Cheng CW;Sedrakyan S;Navarrete G;Dubeau L;Yap LP;Park R;Vinciguerra M;Di Biase S;Mirzaei H;Mirisola MG;Childress P;Ji L;Groshen S;Penna F;Odetti P;Perin L;Conti PS;Ikeno Y;Kennedy BK;Cohen P;Morgan TE;Dorff TB;Longo VD
通讯作者：
Longo VD
影响因子：
3
作者：
Beher, Dirk;Wu, John;Wang, Minghan
通讯作者：
Wang, Minghan
影响因子：
4.8
作者：
Barthel, A;Okino, ST;Roth, RA
通讯作者：
Roth, RA
影响因子：
4.7
作者：
Berrigan, D;Perkins, SN;Hursting, SD
通讯作者：
Hursting, SD