Frailty models: Applications to biomedical and genetic studies
Frailty models: Applications to biomedical and genetic studies
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DOI：
10.1002/sim.4277
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发表时间：
2011-09-30
影响因子：
2
通讯作者：
D'Agostino, R. B., Sr.
中科院分区：
文献类型：
--
作者：
Govindarajulu, Usha S.;Lin, Haiqun;D'Agostino, R. B., Sr.
在生存分析中，脆弱模型是模拟人群中无法解释的异质性的潜在选择。本教程介绍了生物医学和遗传研究背景下的脆弱性建模和乘法危害模型估计的概述和一般框架。脆弱性模型中的其他主题，如模型充分性的诊断方法和脆弱性模型中的推理，也进行了讨论。提供了在生物医学数据集的非参数危害设置中使用多变量脆弱性模型的分析示例，并讨论了选择使用脆弱性及其与遗传应用的相关性的含义。版权所有：John Wiley & Sons， Ltd。
In survival analysis, frailty models are potential choices for modeling unexplained heterogeneity in a population. This tutorial presents an overview and general framework of frailty modeling and estimation for multiplicative hazards models in the context of biomedical and genetic studies. Other topics in frailty models, such as diagnostic methods for model adequacy and inference in frailty models, are also discussed. Examples of analyses using multivariate frailty models in a non-parametric hazards setting on biomedical datasets are provided, and the implications of choosing to use frailty and relevance to genetic applications are discussed. Copyright (C) 2011 John Wiley & Sons, Ltd.