Fast and convenient divergent synthesis of aliphatic ester dendrimers by anhydride coupling
Fast and convenient divergent synthesis of aliphatic ester dendrimers by anhydride coupling
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DOI：
10.1021/ja010524e
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发表时间：
2001-06-27
影响因子：
15
通讯作者：
Fréchet, JMJ
中科院分区：
文献类型：
--
作者：
Ihre, H;De Jesús, OLP;Fréchet, JMJ
以2，2-二羟甲基丙酸的缩醛保护酸酐衍生物为酰化剂，发展了一种新的合成树枝状脂肪族聚酯结构的发散方法。这种发散合成是显著的，因为与所有其他合成不同，它只需要少量过量的试剂来实现定量生长，并且除了简单的溶剂萃取或沉淀之外，它不需要纯化手段。以1，1，1-三羟苯基乙烷为核分子，高产率、高纯度地合成了分子量为30 711道尔顿、含192个掩蔽羟基的单分散第六代树枝状大分子。线性和星形的聚（乙二醇）（PEG）衍生物的窄的多分散性也被用来作为核心分子的发散合成的树枝状线性共聚物杂交到第四代，而不需要任何色谱纯化。
A novel divergent approach was developed for the synthesis of dendritic aliphatic polyester structures using an acetal-protected anhydride derivative of 2,2-bis(hydroxymethyI)propionic acid as the acylating agent. This divergent synthesis is remarkable, because unlike all others, it only requires a small excess of reagent to achieve quantitative growth, and it requires no means of purification other than a simple solvent extraction or precipitation. A monodisperse sixth generation dendrimer with molecular weight of 30 711 Dalton and 192 masked hydroxyl groups was prepared in high yield and purity using 1,1,1 -tris(hydroxyphenyl)ethane as the core molecule. Linear and star-shaped poly(ethylene glycol) (PEG) derivatives of narrow polydispersity were also used as core molecules in the divergent synthesis of dendritic-linear copolymer hybrids up to the fourth generation without requiring any chromatographic purification.