Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface
Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface
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DOI：
10.1021/nl050542k
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发表时间：
2005-09-01
期刊：
影响因子：
10.8
通讯作者：
Blasie, JK
中科院分区：
文献类型：
--
作者：
Ye, SX;Discher, BM;Blasie, JK
四螺旋束肽家族被设计为两亲性的，沿着束外部的长度具有不同的亲水性和疏水性结构域。这有利于它们在极性和非极性介质之间的软界面上进行矢量插入。他们的设计现在还提供了在每个结构域内选择性掺入电子供体和受体辅因子。这使得设计的分子内电子沿束轴转移转化为跨界面的宏观电荷分离。
A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior. This facilitates their vectorial insertion across a soft interface between polar and nonpolar media. Their design also now provides for selective incorporation of electron donor and acceptor cofactors within each domain. This allows translation of the designed intramolecular electron transfer along the bundle axis into a macroscopic charge separation across the interface.