Silk fibroin-assisted exfoliation and functionalization of transition metal dichalcogenide nanosheets for antibacterial wound dressings
Silk fibroin-assisted exfoliation and functionalization of transition metal dichalcogenide nanosheets for antibacterial wound dressings
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DOI：
10.1039/c7nr06807g
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发表时间：
2017-11-28
期刊：
影响因子：
6.7
通讯作者：
Yang, Huang-Hao
中科院分区：
文献类型：
--
作者：
Huang, Xiao-Wei;Wei, Jing-Jing;Yang, Huang-Hao
二维过渡金属二卤代化合物(TMD)因其迷人的性质和潜在的应用而迅速引起人们的关注。然而，制备TMD纳米薄片及其功能复合材料的可伸缩性和低成本方法仍然是有限的。在这里，我们开发了一种简便、环保的方法，以丝素蛋白为剥离剂，在水介质中大规模生产TMD纳米薄片。具体地说，羧基修饰的丝素蛋白显著提高了剥离效率，实现了高产率生产具有良好溶液稳定性和良好生物相容性的薄层MoSe_2纳米片。强的结合作用使得到的MoSe纳米片具有前所未有的高浓度。利用丝素蛋白的溶液可加工性，可以很容易地将MoSe2杂化纳米片制备成宏观的独立膜。此外，由于MoSe2纳米片具有优异的类过氧化物酶活性，在体内使用低剂量的过氧化氢，可以避免传统医学治疗中高剂量过氧化氢的副作用，从而显示出快速有效的伤口消毒和愈合效果。这项工作可能为将二维TMD纳米片应用于临床提供新的机会。
Two-dimensional transition metal dichalcogenides (TMDs) have attracted rapidly increasing attention due to their fascinating properties and potential applications. However, scalable and cost-effective methods to produce thin-layer TMD nanosheets and their functional composites with environmental benignity are still limited. Herein, we develop a facile and environmentally friendly method for the scalable production of thin-layer TMD nanosheets in an aqueous medium by using silk fibroin, a natural and abundant biopolymer, as the exfoliating agent. Specifically, carboxyl-modified silk fibroin significantly improves the exfoliation efficiency, achieving the high-yield production of thin-layer MoSe2 nanosheets with good solution stabilization and excellent bio-compatibility. Strong binding interactions endow the resultant MoSe2 nanosheets with unprecedentedly high concentrations. By virtue of the solution-processability of silk fibroin, MoSe2 hybrid nanosheets are readily fabricated into macroscopic freestanding films. Furthermore, due to the superior peroxidase-like activity of MoSe2 nanosheets, MoSe2-based films show rapid and effective wound disinfection and healing efficacy with the use of low-dose H2O2 in vivo, avoiding the side effects of high-dose H2O2 in traditional medical therapy. This work may offer new opportunities to apply two-dimensional TMD nanosheets for clinical applications.