Nonprogressive glaucomatous cupping and visual field abnormalities in young Chinese males
Nonprogressive glaucomatous cupping and visual field abnormalities in young Chinese males
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DOI：
10.1016/j.ophtha.2006.07.036
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发表时间：
2007-03-01
期刊：
影响因子：
13.7
通讯作者：
Singh, Kuldev
中科院分区：
文献类型：
--
作者：
Doshi, Amish;Kreidl, Ken O.;Singh, Kuldev
目的：描述一系列的年轻到中年男性的中国血统谁提出了一个星座的眼睛的结果提示青光眼，被发现是稳定的7年period.Design：Retrospective case series.Participants：16名25- 66岁的男性patients.Methods：病历的参与者，中国血统，并提到青光眼评价超过7年的时间，进行了审查。所有患者均接受完整的眼科检查、视神经立体成像和自动视野检查。在这一实践中，不到5%的患者是中国人。观察患者的研究期间，在一个单一的青光眼clinic.Main结果Measures：视野（VF）的变化或进行性视神经cupping提示glaucoma.Results：患者的平均年龄为38.9岁。75.0%（24/32）的神经盘倾斜，81.3%（26/32）的神经乳头周围萎缩。杯盘比范围为0.20至0.95，平均为0.56。任何患者在任何时间的最低眼内压（IOP）为8 mmHg，而最高为29 mmHg（平均范围，13.5-17.9）。56.3%（9/16）的患者接受了降眼压治疗。25.0%（4/16）的患者有青光眼家族史。高度近视（>-6.00屈光度等效球镜[SE]）占43.8%（14/32），SE范围为-11.25 ~+0.25。最常见的VF缺损为弓形缺损，见于31.3%（10/32）的患者。在此期间，未发现具有类似结果的中国女性。无论是视神经，也没有显着的VF进展被发现在后续的时间，无论使用的降眼压therapy.Conclusions：这些年轻的中国患者以前诊断为青光眼或认为青光眼嫌疑人有稳定的眼部检查结果长达7年，无论降眼压治疗。他们的病情与近视和椎间盘倾斜有关。许多人正在接受降低眼压的青光眼治疗，他们可能没有这种情况。需要进一步的前瞻性流行病学研究来确定这种非进展性结果的集合是否在中国年轻男性中比在普通人群中更常见。
Objective: To describe a series of young to middle-aged men of Chinese origin who presented with a constellation of ocular findings suggestive of glaucoma, that were found to be stable over a 7-year period.Design: Retrospective case series.Participants: Sixteen 25- to 66-year-old male patients.Methods: Medical records of the participants, of Chinese origin and referred for glaucoma evaluation over a 7-year period, were reviewed. All patients underwent complete ophthalmic examinations, stereo imaging of the optic nerves, and automated perimetry. Fewer than 5% of all patients seen in this practice were of Chinese origin. The patients were observed for the duration of the study in a single glaucoma clinic.Main Outcome Measures: Visual field (VF) changes or progressive optic nerve cupping suggestive of glaucoma.Results: The patients had an average age of 38.9 years. Tilted discs were present in 75.0% (24/32) and peripapillary atrophy in 81.3% (26/32) of nerves. Cup-to-disc ratios ranged from 0.20 to 0.95 and averaged 0.56. The lowest intraocular pressure (IOP) in any patient at any time was 8 mmHg, whereas the highest was 29 (average range, 13.5-17.9). Intraocular pressure-lowering therapy had been used in 56.3% (9/16). There was a family history of presumed glaucoma in 25.0% (4/16) of patients. High myopia (>-6.00-diopter spherical equivalent [SE]) was present in 43.8% of eyes (14/32), and SEs ranged from -11.25to +0.25. The most common VF defect was an arcuate defect, found in 31.3% (10/32) of patients. There were no females of Chinese origin with similar findings identified during this period. Neither optic nerve nor significant VF progression was found during the follow-up period, regardless of the use of IOP-lowering therapy.Conclusions: These young Chinese patients previously diagnosed with glaucoma or considered glaucoma suspects had stable ocular findings for up to 7 years, irrespective of IOP-lowering therapy. Their condition was associated with myopia and tilted discs. Many were being treated with IOP-lowering therapy for glaucoma, a condition they may not have had. Further prospective epidemiologic study is needed to determine whether such a constellation of nonprogressive findings is more common in young Chinese males than in the general population.