[B-cell lymphoma/leukemia-2 and benign prostatic hyperplasia].
[B-cell lymphoma/leukemia-2 and benign prostatic hyperplasia].
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发表时间：
2009-05
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通讯作者：
Min-Dao Zhang;Yong-Ning Zhao;Li-wen An
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作者：
Min-Dao Zhang;Yong-Ning Zhao;Li-wen An
B细胞淋巴瘤/白血病-2（Bcl-2）基因是Bcl-2家族的重要成员，Bcl-2家族是一种在细胞凋亡过程中起重要作用的蛋白质。Bcl-2不改变细胞增殖速率，但通过对抗一系列凋亡而延长细胞寿命并增加细胞数量。近年来，越来越多的证据表明Bcl-2基因与良性前列腺增生（BPH）的发生、发展密切相关，BPH的发病机制尚未完全阐明，但细胞凋亡的作用正引起越来越多的关注。
The B-cell lymphoma/leukemia-2 (Bcl-2) gene is an important member of the Bcl-2 family, a type of protein that plays an important role in the process of cell apoptosis. Bcl-2 does not change the rate of cell proliferation, but prolongs the life and increases the number of cells by counteracting a series of apoptosis. In the recent years, more and more evidence has shown a close correlation of the Bcl-2 gene with the development and progression of benign prostatic hyperplasia (BPH), a disease whose mechanism is not yet fully understood but is drawing more and more attention towards the role of cell apoptosis.