Setting appropriate boundaries: fate, patterning and competence at the neural plate border.

Setting appropriate boundaries: fate, patterning and competence at the neural plate border.
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设定适当的界限:神经板边界的命运、模式和能力。

DOI:
10.1016/j.ydbio.2013.11.027
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发表时间:
2014-05-01
影响因子:
2.7
通讯作者:
LaBonne, Carole
LaBonne, Carole
中科院分区:
生物学3区
文献类型:
--
作者:
Groves, Andrew K.;LaBonne, Carole

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神经嵴和颅面基板是出现在脊椎动物神经板边界的两个不同的祖细胞群。该边界区域通过一系列诱导相互作用而发展,这些相互作用在原肠胚形成之前开始,并逐渐将胚胎外胚层分为神经区域和非神经区域,随后出现神经嵴和基板祖细胞。在这篇综述中,我们描述了有限的诱导信号(主要是 FGF、Wnt 和 BMP)如何在边界区域建立转录因子域,通过交叉抑制和交叉自动调节相互作用建立这些祖细胞区域。这些相互作用产生的不同转录因子群的逐渐组装是一种提供以不同方式响应感应信号的能力的机制,最终产生神经嵴和颅板。
The neural crest and craniofacial placodes are two distinct progenitor populations that arise at the border of the vertebrate neural plate. This border region develops through a series of inductive interactions that begin before gastrulation and progressively divide embryonic ectoderm into neural and non-neural regions, followed by the emergence of neural crest and placodal progenitors. In this review, we describe how a limited repertoire of inductive signals – principally FGFs, Wnts and BMPs – set up domains of transcription factors in the border region which establish these progenitor territories by both cross-inhibitory and cross-autoregulatory interactions. The gradual assembly of different cohorts of transcription factors that results from these interactions is one mechanism to provide the competence to respond to inductive signals in different ways, ultimately generating the neural crest and cranial placodes.
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