A European myocardial 123I-mIBG cross-calibration phantom study
A European myocardial 123I-mIBG cross-calibration phantom study
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DOI：
10.1007/s12350-017-0782-6
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发表时间：
2018-08-01
影响因子：
2.4
通讯作者：
Verberne, Hein J.
中科院分区：
文献类型：
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作者：
Verschure, Derk O.;Poel, Edwin;Verberne, Hein J.
瞄准。平面心肌I-123-间碘苯基胍(I-123-MIBG)显像是一种重复性很高的技术。然而，准直器使用的差异是导致不同机构和研究之间心脏与纵隔(H/M)比率差异的最重要因素之一。因此，各种伽马相机-准直器组合之间的标准化是必要的。此前，日本已经开发了一种体模来交叉校准不同的采集条件。为了进一步对欧洲心肌I-123-MIBG成像进行交叉校准，本研究的目的是从欧洲常见的伽马相机供应商那里收集I-123-MIBG的H/M比值数据。在27个欧洲机构进行了210项实验。在这些实验的基础上，计算了每种伽马相机-准直器组合的转换系数。用平均换算系数0.88计算标准化H/M比。平均而言，LE-准直器来源的H/M比率显著低于ME-准直器来源的H/M比率。LE-准直器组的平均换算系数为0.553-0.605，ME-准直器组的平均换算系数为0.824-0.895。临床上建立的H/M比率可以使用交叉校准的换算系数转换成标准化的H/M比率。这一标准化对于确定适当的风险分层阈值非常重要。此外，这种交叉校准能够在不同的国家和国际数据之间进行比较。
Aim. Planar myocardial I-123-meta-iodobenzylguanidine (I-123-mIBG) scintigraphy is a highly reproducible technique. However, differences in collimator use are one of the most important factors that cause variation among institutions and studies in heart-to-mediastinum (H/M) ratio. Therefore, standardization among various gamma camera-collimator combinations is needed. Previously, a phantom has been developed to cross-calibrate different acquisition conditions in Japan. For further cross-calibration of European myocardial I-123-mIBG imaging, the aim of this study was to collect I-123-mIBG data for H/M ratios from common European gamma camera vendors.Methods. 210 experiments were performed in 27 European institutions. Based on these experiments, conversion coefficients for each gamma camera-collimator combination were calculated. An averaged conversion coefficient of 0.88 was used to calculate a standardized H/M ratio.Results. On average, LE-collimator-derived H/M ratios were significantly lower compared to ME-collimator-derived H/M ratios. The mean conversion coefficients ranged from 0.553 to 0.605 for the LE-collimator group and from 0.824 to 0.895 for the ME-collimator group.Conclusion. Clinically established H/M ratios can be converted into standardized H/M ratios using cross-calibrated conversion coefficients. This standardization is important for identifying appropriate thresholds for adequate risk stratification. In addition, this cross-calibration enables comparison between different national and international data.