Effects of long term device-guided slow breathing on sympathetic nervous activity in hypertensive patients: a randomized open-label clinical trial
Effects of long term device-guided slow breathing on sympathetic nervous activity in hypertensive patients: a randomized open-label clinical trial
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DOI：
10.1080/08037051.2017.1357109
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发表时间：
2017-01-01
期刊：
影响因子：
1.8
通讯作者：
Mion, Decio
中科院分区：
文献类型：
--
作者：
de Barros, Silvana;da Silva, Giovanio Vieira;Mion, Decio
目的：设备引导的慢呼吸（DGB）被认为是高血压的非药物治疗方法。交感神经活动（SNA）减少可能是血压（BP）降低的机制之一。本研究的目的是评估 DGB 在 BP 和 SNA 中的长期使用。 受试者和方法：高血压患者被随机分配听音乐（对照组-CG）或 DGB（旨在将呼吸频率降低至低于 10 次呼吸/分钟，每天 15 分钟，持续 8 周）。干预前后通过显微神经造影进行动态血压监测 (ABPM)、儿茶酚胺和肌肉交感神经活动 (MSNA)。结果：DGB 中的 17 名志愿者和 CG 中的 15 名志愿者完成了研究。两组干预前后诊室血压均无变化。仅 CG 中的 ABPM 可使清醒期的收缩压和舒张压降低（13110/929 vs 128 +/- 10/88 +/- 8mmHg，p
Purpose: Device-guided slow breathing (DGB) is indicated as nonpharmacological treatment for hypertension. The sympathetic nerve activity (SNA) reduction may be one of the mechanisms involved in blood pressure (BP) decrease. The aim of this study is to evaluate the long-term use of DGB in BP and SNA.Subjects and methods: Hypertensive patients were randomized to listen music (Control Group-CG) or DGB (aim to reduce respiratory rate to less than 10 breaths/minute during 15minutes/day for 8 weeks). Before and after intervention ambulatory blood pressure monitoring (ABPM), catecholamines and muscle sympathetic nerve activity (MSNA) by microneurography were performed.Results: 17 volunteers in the DGB and 15 in the CG completed the study. There was no change in office BP before and after intervention in both groups. There was a reduction in systolic and diastolic BP in the awake period by ABPM only in the CG (13110/929 vs 128 +/- 10/88 +/- 8mmHg, p