Dual constant composition kinetics characterization of apatitic surfaces.
Dual constant composition kinetics characterization of apatitic surfaces.
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磷灰石表面的双常数组成动力学表征。
DOI：
10.1002/jbm.820281205
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Nancollas,GH
中科院分区：
文献类型：
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作者：
Paschalis,EP;Wikiel,K;Nancollas,GH
磷酸钙相作为植入物材料的使用形式，如陶瓷羟基磷灰石（CMC）和羟基磷灰石等离子涂层植入物（HPCTI）以及合成相，现在已经相当成熟。虽然常规的物理化学表征方法如X射线衍射可能表明羟基磷灰石（HAP）的唯一存在，但毫无疑问，其他含钙表面杂质在这些材料与水相接触时发生的初始反应中起着重要作用。这些表面杂质通常会迅速溶解，释放出过量的钙离子和氢氧根离子。在恒组成（CC）法的基础上，发展了双恒组成（DCC）法来研究这类磷灰石材料的溶解动力学行为，并可能预测其在体内放置时的行为。本研究的结果证实了在材料表面存在高反应性的非均相含钙相，例如，HPCTI，如通过在将这些表面引入盐水溶液中时释放可观量的钙离子和氢氧根离子所证明的。此外，当与合成制备的相如HAP和β-磷酸三钙（β-TCP）相比时，这些磷酸钙相表现出独特的溶解行为，如通过观察到它们溶解在相对于HAP过饱和的溶液中所表明的。John Wiley & Sons，Inc.
The use of calcium phosphate phases as implant materials in forms such as ceramic hydroxyapatite (CHAP) and hydroxyapatite plasma‐coated implants (HPCTI) as well as the synthetic phases is now quite well established. Although conventional physical chemical charaterization methods such as X‐ray diffraction may indicate the exclusive presence of hydroxyapatite (HAP), there is little doubt that other calcium‐containing surface impurities play important roles in the initial reactions that take place when such materials are brought into contact with aqueous phases. These surface impurities usually dissolve rapidly with the release of excess calcium and hydroxide ions. Based on the constant composition (CC) method, the dual constant composition (DCC) approach has been developed for investigating the dissolution kinetics behavior of these apatitic materials in an attempt to characterize and modify the surfaces, and possibly to predict their behavior when placedin vivo.The results of this study confirm the presence of highly reactive heterogeneous calcium‐containing phases on the surface of materials such as CHAP and HPCTI, as evidenced by the release of appreciable amounts of calcium and hydroxyl ions upon introduction of these surfaces in saline solutions. Furthermore, these calcium phosphate phases exhibited a unique dissolution behavior when compared with synthetically prepared phases such as HAP and β‐tricalcium phosphate (β‐TCP), as suggested by the observation that they dissolve in solutions supersaturated with respect to HAP. © 1994 John Wiley & Sons, Inc.