The potential prognostic values of the ADAMTS-like protein family: an integrative pan-cancer analysis.
The potential prognostic values of the ADAMTS-like protein family: an integrative pan-cancer analysis.
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ADAMTS 样蛋白家族的潜在预后价值：综合泛癌分析。
DOI：
10.21037/atm-21-4946
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发表时间：
2021-10
影响因子：
--
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Zhang X;Yang W;Chen K;Zheng T;Guo Z;Peng Y;Yang Z
具有 1 型血小板反应蛋白基序 (ADAMTS) 样蛋白的解整合素样和金属蛋白酶结构域，包括 ADAMTSL1-6 和乳头蛋白（属于哺乳动物 ADAMTS 超家族的一部分），似乎与细胞外基质功能和 ADAMTS 蛋白酶活性的调节相关。它们在肿瘤发生和进展以及调节肿瘤微环境（TME）中的作用现已得到认可。在本研究中，通过整合癌症基因组图谱 (TCGA) 数据和带注释的数据资源，对 ADAMTSL 的泛癌效应及其与患者生存、药物反应和 TME 的关系进行了全面调查。研究发现 ADAMTSL 家族成员的表达在许多癌症类型中失调。更重要的是，它们的表达通常与患者的总生存期 (OS)、药物反应和 TME 相关。 ADAMTSL1、ADAMTSL4 和 ADAMTSL5 主要与侵袭性表型相关，而 PAPLN 更常与良好预后相关。在非小细胞肺癌 (NSCLC) 队列中，基因表达综合存储库 (GSE135222) 样本中含有 4 型血小板反应蛋白 (THSD4) (ADAMTSL6) 和 Papilin (PAPLN) 的免疫检查点抑制剂 (ICI) 敏感性与免疫检查点抑制剂 (ICI) 敏感性相关。通过对 18 名中国肺腺癌患者的蛋白质组学分析，分别鉴定出 20 种和 30 种与 THSD4 和 PAPLN 相关的蛋白质。我们的研究结果加深了对 ADAMTSL 家族在癌症中作用的理解，并且是其临床应用的宝贵资源。本文深入探讨了下一代测序技术的临床重要性，以识别用于预后的新型生物标志物并研究临床获益的治疗策略。
A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs (ADAMTS)-like proteins, including ADAMTSL1-6 and papilin, which are part of the mammalian ADAMTS superfamily, appear to be relevant to extracellular matrix function and the regulation of ADAMTS protease activity. Their roles in tumor initiation and progression and regulating the tumor microenvironment (TME) are now recognized. In the present study, a comprehensive investigation of the pan-cancer effects of ADAMTSLs and their associations with patient survival, drug responses, and the TME was performed by integrating The Cancer Genome Atlas (TCGA) data and annotated data resources. The expression of ADAMTSL family members was found to be dysregulated in many cancer types. More importantly, their expression was frequently associated with patients’ overall survival (OS), drug responses, and the TME. ADAMTSL1, ADAMTSL4, and ADAMTSL5 were primarily associated with aggressive phenotypes, while PAPLN was more frequently associated with a favorable prognosis. In a non-small cell lung cancer (NSCLC) cohort, Thrombospondin Type 1 Domain Containing 4 (THSD4) (ADAMTSL6) and Papilin (PAPLN) were associated with immune checkpoint inhibitor (ICI) sensitivity in samples from the Gene Expression Omnibus repository (GSE135222). Twenty and 30 proteins related to THSD4 and PAPLN, respectively, were identified through a proteomic analysis of 18 Chinese lung adenocarcinoma patients. Our findings extend understandings of the role of the ADAMTSL family in cancers and are a valuable resource on their clinical utility. This article provides insight into the clinical importance of next-generation sequencing technology to identify novel biomarkers for prognosis and investigate therapeutic strategy for clinical benefit.
影响因子：
4.6
作者：
Honda H;Takamura M;Yamagiwa S;Genda T;Horigome R;Kimura N;Setsu T;Tominaga K;Kamimura H;Matsuda Y;Wakai T;Aoyagi Y;Terai S
通讯作者：
Terai S