P069 Investigating the impact of insulin resistance on ageing and wellbeing using sleep as a model system
P069 Investigating the impact of insulin resistance on ageing and wellbeing using sleep as a model system
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P069 使用睡眠作为模型系统研究胰岛素抵抗对衰老和健康的影响
DOI：
10.1136/bmjresp-2019-bssconf.69
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Zhu G
中科院分区：
文献类型：
--
作者：
Zhu G
由昼夜节律控制的睡眠对于许多功能都是必不可少的，包括能量保存，记忆巩固和大脑处理。睡眠时间和结构随年龄而变化。睡眠剥夺在现代社会中非常普遍，已被确定为许多代谢性疾病的主要可改变的危险因素。使用触摸屏问卷收集社会人口统计学、健康相关和生活方式信息。使用腕戴式加速度计客观测量睡眠和身体活动参数（参与者年龄为43-79岁）。睡眠时间被分为五组。短轨枕：（1）<5小时/夜，（2）5-6小时/夜，（3）6-7小时/夜，正常睡眠者：（4）7-8小时/夜，长时间睡眠者：（5）>8小时/夜。睡眠时间<5小时/晚的男性中，腰围（> 102厘米）的风险较高的比例高于正常睡眠者和长睡眠者（分别为22.1%、14.9%、11.7%、10.4%和10.2%）。在女性中也观察到类似的模式（分别为60.0%、50.6%、43.9%、41.3%和40.6%）。与其他睡眠时间短和睡眠时间长的人相比，睡眠时间在6-8小时之间的人患有心脏代谢疾病的比例明显较低（分别为34.8%，27.7%，26.0%，25.9%和29.1%）。他们也有更好的健康评级，不太可能患高血压，糖尿病和心血管疾病。最后，与其他睡眠组相比，睡眠6-7小时的人身体活动最多。总之，每晚6-8小时的睡眠与更好的代谢健康和更高的体力活动水平有关。睡眠时间短与男性性别和社会剥夺有关。虽然这项研究没有建立因果关系，但结果可以帮助为目标群体制定干预措施，以减少睡眠不良的不良影响。
Sleep controlled by the circadian rhythm is essential for many functions including energy conservation, memory consolidation and brain processing. Sleep duration and architecture changes with age. Sleep deprivation is very common in modern society and it has been identified as a major modifiable risk factor for many metabolic diseases.A cross-sectional analysis was carried out on baseline data from the UK Biobank (n=82995). Sociodemographic, health-related and lifestyle information were collected using touch-screen questionnaires. Sleep and physical activity parameters were measured objectively using wrist-worn accelerometers (participants were aged 43–79 years). Sleep durations have been categorised into five groups. short sleepers: (1) <5 hours/night, (2) 5–6 hours/night, (3) 6–7 hours/night; normal sleepers: (4) 7–8 hours/night; long sleepers: (5) >8 hours/night.Short objective sleep duration was associated with male gender, older age and lower social status. A greater proportion of males with a sleep duration <5 hours/night have very high risk waist circumference (>102cm) compared to normal and long sleepers (22.1%, 14.9%, 11.7%, 10.4% and 10.2%, respectively). A similar pattern was also seen in females (60.0%, 50.6% 43.9%, 41.3% and 40.6%, respectively). The percentage of participants with cardiometabolic diseases is significantly lower in those who sleep between 6–8 hours/night compared to other short and long sleepers (34.8%, 27.7%, 26.0%, 25.9% and 29.1%, respectively). They also have better health ratings and less likely to have hypertension, diabetes and cardiovascular disease. Finally, those who sleep 6–7 hours were most physically active compared to other sleep groups. In conclusion, 6–8 hours of sleep per night is associated with better metabolic health and higher physical activity level. Short sleep duration is associated with male gender and social deprivation. Although, no causal link can be established from this study, the results can help to develop interventions for targeted groups to reduce the adverse effects of poor sleep.