VA/Q inhomogeneity and AaDO2 in man during exercise: effect of SF6 breathing.
VA/Q inhomogeneity and AaDO2 in man during exercise: effect of SF6 breathing.
复制标题
运动期间人体 VA/Q 不均匀性和 AaDO2：SF6 呼吸的影响。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
A. Bryan
中科院分区：
文献类型：
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作者：
N. Gledhill;A. Froese;F. Buick;A. Bryan
研究了五名正常受试者在休息时和在自行车测力计上进行适度稳态运动时的肺气体交换，同时呼吸 a) 室内空气和 b) 20.9% O2 平衡六氟化硫 (SF6) 的混合物。从休息到运动，肺泡动脉氧压差（AaDO2）显着扩大。呼吸 O2-SF6 混合物使 AaDo2 显着降低，在休息时从 10.9 托降低到 4.2 托，在运动时从 15.5 托降低到 10.1 托（P 小于或等于 0.01）。 SF6 呼吸期间，新陈代谢、心输出量或心率没有同时发生变化。解剖分流分数、肺泡毛细血管末端平衡或血流分布的可能变化不能解释这些观察结果。我们得出的结论是，运动期间 AaDO2 的增加反映了通气-灌注比 (VA/Q) 的不均匀性，最有可能出现在肺区域内（区域内不均匀性），而不是区域之间（区域间不均匀性）。
Pulmonary gas exchange was studied in five normal subjects both at rest and during moderate steady-state exercise on a bicycle ergometer while breathing a) room air and b) a mixture of 20.9% O2-balance sulfur hexafluoride (SF6). The alveolar-arterial oxygen pressure differences (AaDO2) widened significantly from rest to exercise. Breathing the O2-SF6 mixture reduced the AaDo2 significantly from 10.9 to 4.2 Torr at rest and from 15.5 to 10.1 Torr during exercise (P less than or equal to 0.01). There were no concurrent changes in metabolism, cardiac output, or heart rate during the SF6 breathing. Possible changes in the anatomic shunt fraction, alveolar-end-capillary equilibration, or the distribution of blood flow cannot account for these observations. We conclude that the AaDO2 increase during exercise reflects an inhomogeneity of ventilation-perfusion ratios (VA/Q) most probably arising within regions of the lung (intraregional inhomogeneity) rather than between regions (interregional inhomogeneity).