Elevated NLR in gallbladder cancer and cholangiocarcinoma - making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium
Elevated NLR in gallbladder cancer and cholangiocarcinoma - making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium
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DOI：
10.1016/j.hpb.2016.08.006
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发表时间：
2016-11-01
期刊：
影响因子：
2.9
通讯作者：
Schmidt, Carl R.
中科院分区：
文献类型：
--
作者：
Beal, Eliza W.;Wei, Lai;Schmidt, Carl R.
背景：胆囊和肝外胆道恶性肿瘤是侵袭性肿瘤，具有很高的复发和死亡风险。我们假设，术前中性粒细胞-淋巴细胞比率 (NLR) 升高与接受胆囊切除或肝外胆管癌的患者预后不良相关。 方法：从 10 个学术中心 (n=525) 中筛选出 2000 年至 2014 年期间接受完整手术切除的患者。通过对 NLR 正常 (5) 的患者进行分层来分析总生存期 (OS) 和无复发生存期 (RFS)。结果：总体而言，375 名患者的 NLR 为 5。NLR5 患者的中位 OS 为 24.5 个月（p5，呼吸困难和术前胆红素峰值与胆囊癌患者的 OS 独立相关。NLR5 患者的中位 RFS 为 26.8 个月（p=0.030）。 NLR > 5 与胆囊癌患者较差的 RFS 独立相关。结论：NLR 升高与胆囊癌和肝外胆管癌患者在治疗性切除后的较差预后相关，并且可以提供重要的预后信息。
Background: Gallbladder and extrahepatic biliary malignancies are aggressive tumors with high risk of recurrence and death. We hypothesize that elevated preoperative Neutrophil-Lymphocyte Ratios (NLR) are associated with poor prognosis among patients undergoing resection of gallbladder or extrahepatic biliary cancers.Methods: Patients who underwent complete surgical resection between 2000-2014 were identified from 10 academic centers (n=525). Overall (OS) and recurrence-free survival (RFS) were analyzed by stratifying patients with normal (5) NLR.Results: Overall, 375 patients had NLR 5. Median OS was 24.5 months among patients with NLR5 (p5, dyspnea and preoperative peak bilirubin were independently associated with OS in patients with gallbladder cancer. Median RFS was 26.8 months in patients with NLR5 (p=0.030). NLR>5 was independently associated With worse RFS for patients with gallbladder cancer.Conclusions: Elevated NLR was associated with worse outcomes in patients with gallbladder and extrahepatic biliary cancers after curative-intent resection. NLR is easily measured and may provide important prognostic information.