SLOW AXOPLASMIC-TRANSPORT - A FICTION
SLOW AXOPLASMIC-TRANSPORT - A FICTION
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DOI：
10.1016/s0022-5193(85)80028-x
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发表时间：
1985-01-01
影响因子：
2
通讯作者：
TORRES, JC
中科院分区：
文献类型：
--
作者：
ALVAREZ, J;TORRES, JC
在轴浆中未观察到核糖体。这导致了这样的概念，即核周体是神经元蛋白质的唯一来源，轴质是由（缓慢）运输机制提供的。这两个概念受到质疑，因为它们无法根据生物学知识的主体来解释真实的神经元。例如，胞体的合成速率或轴浆蛋白的寿命应该超出动物细胞的已知范围，并且如果从一端进料，则不可能产生均匀的轴突。另一种观点提出了轴突的维护，它接受了有争议的蛋白质轴浆合成的想法;因此，缓慢的运输变得不必要。这一观点给出了一个定性的说明的意见处理的维护轴质。为了以更定量的方式解释这种现象，进行了计算机模拟，其中程序的方程仅提供蛋白质的轴浆合成;检索到的一组曲线与迄今为止被认为支持缓慢运输概念的实验结果非常一致。缓慢轴浆运输的概念一直是对良好观察结果的误解，因为参考系不完整，没有提供蛋白质的轴浆合成。
Ribosomes have not been observed in axoplasm. This had led to the notions that the perikaryon is the only source of neuronal proteins and that the axoplasm is supplied by a (slow) transport mechanism. These 2 notions were questioned because they are unable to give an account of real neurones in accordance with the body of biological knowledge. For example, the synthetic rate of perikarya or the life span of axoplasmic proteins should be beyond known ranges for animal cells and a uniform axon is unlikely to result if it is fed from one end. An alternative view was proposed for the maintenance of the axon which accepts the controversial idea of axoplasmic synthesis of proteins; as a result, the slow transport becomes unnecessary. This view gives a qualitative account of the observations dealing with the maintenance of the axoplasm. To account for the phenomenology in a more quantitative fashion, a computer simulation was carried out where the equations of the program provided only for axoplasmic synthesis of proteins; the set of curves retrieved were in good agreement with experimental findings believed so far to support the notion of slow transport. The notion of slow axoplasmic transport has been a misinterpretation of good observations because the frame of reference was incomplete in not providing for axoplasmic synthesis of proteins.