Five new koumine-type alkaloids from the roots of Gelsemium elegans
Five new koumine-type alkaloids from the roots of Gelsemium elegans
复制标题
钩吻根中的五种新的苯胺型生物碱
DOI：
10.1016/j.fitote.2017.03.004
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发表时间：
2017-04-01
期刊：
影响因子：
3.4
通讯作者：
Ye, Wen-Cai
中科院分区：
文献类型：
--
作者：
Zhang, Wei;Zhang, Sheng-Yuan;Ye, Wen-Cai
从钩吻根中分离出 5 种新的 koumine 型生物碱 (1-5) 以及 6 种已知的生物碱。基于核磁共振波谱和电子圆二色光谱分析阐明了它们的绝对构型结构。通过 MIT 测定评估化合物 1-11 对三种肿瘤细胞系（A-649、HepG2 和 HuH7）活力的抑制作用。 (C) 2017 Elsevier B.V. 保留所有权利。
Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viability of three tumor cell lines (A-649, HepG2, and HuH7) were evaluated by the MIT assay. (C) 2017 Elsevier B.V. All rights reserved.