Effects of 17β-estradiol on synaptic plasticity in the rat medial vestibular nuclei
Effects of 17β-estradiol on synaptic plasticity in the rat medial vestibular nuclei
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DOI：
10.1080/00016480802566287
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发表时间：
2009-01
影响因子：
1.4
通讯作者：
S. Grassi;A. Frondaroli;Cristina V. Dieni;M. Scarduzio
中科院分区：
文献类型：
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作者：
S. Grassi;A. Frondaroli;Cristina V. Dieni;M. Scarduzio
结论：本研究表明，17β-雌二醇（E2）可以放大高频刺激（HFS）在前庭核中诱导的长时程增强（LTP），而单独由E2诱导的与突触高频激活无关的增强可被HFS逆转。目的：与 HFS 一样，外源性 E2 通过 NMDA 受体激活，诱导内侧前庭核 (MVN) 中前庭传入刺激的突触反应持久增强。本研究的目的是验证 E2 和 HFS 在诱导 LTP 中可能存在的相互作用。材料和方法：在大鼠脑干切片中，我们分析了通过以下方式在 MVN 中诱发的场电位中诱导的变化：1）诱导 E2 效应后递送的 HFS 和 2）诱导 HFS-LTP 后施加的 E2。结果：在大多数情况下，HFS 逆转了 E2 诱导的增强作用，而 E2 能够增加 HFS 诱导的增强作用的幅度。
Conclusion: This study shows that 17β-estradiol (E2) can amplify the long-term potentiation (LTP) induced in the vestibular nuclei by high frequency stimulation (HFS), while potentiation induced by E2 alone, which is unrelated to synaptic high frequency activation, is reversed by HFS. Objective: Like HFS, exogenous E2 induces long-lasting enhancement of synaptic responses to vestibular afferent stimulation in the medial vestibular nuclei (MVN), through NMDA receptor activation. The aim of this study was to verify the possible interaction of E2 and HFS in inducing LTP. Materials and methods: In rat brainstem slices, we analysed the modifications induced in the field potential evoked in the MVN by: 1) HFS delivered after induction of E2 effect and 2) E2 applied after induction of HFS-LTP. Results: HFS reversed the E2-induced potentiation in most cases, while E2 was able to increase the magnitude of potentiation induced by HFS.