Local and distributed PiB accumulation associated with development of preclinical Alzheimer's disease
Local and distributed PiB accumulation associated with development of preclinical Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2015.10.025
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发表时间：
2016-02-01
影响因子：
4.2
通讯作者：
Vlassenko, Andrei G.
中科院分区：
文献类型：
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作者：
Brier, Matthew R.;McCarthy, John E.;Vlassenko, Andrei G.
淀粉样蛋白-β斑块是阿尔茨海默病（AD）的标志，其可以通过淀粉样蛋白成像（例如，Pittsburgh B化合物[Pi B]）并总结为标量值。汇总值可能具有临床实用性，但它是许多感兴趣区域的平均值，可能会掩盖重要的地形图。本研究调查了在基线时具有正常（N = 131）或异常（N = 26）PiB扫描的认知正常老年人中淀粉样蛋白地形图的纵向演变。在3年随访时，16名先前正常PiB扫描的参与者转换为与临床前AD一致的PiB扫描。我们研究了基线和随访PiB地形图之间的多变量关系（典型相关）。此外，我们使用惩罚回归来研究与汇总测量相比，来自PiB地形的附加信息。PiB积累可以是局部的，即，一个地形预测未来的相同地形，和/或分布式的，即，一个地形预测另一个地形。局部和分布的PiB积累与PiB状态的转换有关。此外，多变量拓扑的元素，而不是常用的汇总标量，与未来的PiB变化相关。考虑到整个多变量PiB拓扑提供了关于非常早期临床前AD中淀粉样蛋白β病理学发展的额外信息。(C)2016 Elsevier Inc. All rights reserved.
Amyloid-beta plaques are a hallmark of Alzheimer's disease (AD) that can be assessed by amyloid imaging (e.g., Pittsburgh B compound [PiB]) and summarized as a scalar value. Summary values may have clinical utility but are an average over many regions of interest, potentially obscuring important topography. This study investigates the longitudinal evolution of amyloid topographies in cognitively normal older adults who had normal (N = 131) or abnormal (N = 26) PiB scans at baseline. At 3 years follow-up, 16 participants with a previously normal PiB scan had conversion to PiB scans consistent with preclinical AD. We investigated the multivariate relationship (canonical correlation) between baseline and follow-up PiB topographies. Furthermore, we used penalized regression to investigate the added information derived from PiB topography compared to summary measures. PiB accumulation can be local, that is, a topography predicting the same topography in the future, and/or distributed, that is, one topography predicting another. Both local and distributed PiB accumulation was associated with conversion of PiB status. Additionally, elements of the multivariate topography, and not the commonly used summary scalar, correlated with future PiB changes. Consideration of the entire multivariate PiB topography provides additional information regarding the development of amyloid-beta pathology in very early preclinical AD. (C) 2016 Elsevier Inc. All rights reserved.