A plethora of lesion-replicating DNA polymerases
A plethora of lesion-replicating DNA polymerases
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DOI：
10.1101/gad.13.17.2191
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发表时间：
1999-09-01
影响因子：
10.5
通讯作者：
Woodgate, R
中科院分区：
文献类型：
--
作者：
Woodgate, R
DNA损伤常常对基因组复制造成相当大的阻碍。为了克服这种对DNA复制的阻碍，细胞利用专门的辅助因子，使新生DNA链的合成与阻断病灶相反。最近的研究表明，翻译DNA合成的许多关键参与者属于原核生物、古细菌和真核生物中发现的一个结构相关蛋白大家族。对这些蛋白质的系统发育分析表明，它们可以大致分为四类，以
Lesions in DNA often pose considerable impediments to genome duplication. To overcome this block to DNA replication, cells utilize specialized accessory factors that allow the synthesis of nascent DNA chains opposite the blocking lesion. Recent studies suggest that many of the key participants in translesion DNA synthesis belong to a large family of structurally related proteins that are found in prokaryotes, archaea, and eukaryotes. Phylogenetic analysis of these proteins suggests that they can be subdivided broadly into four groups typified by