Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life.
Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life.
复制标题
终生光感受器和视网膜色素上皮的动态脂质周转。
DOI：
10.1016/j.preteyeres.2021.101037
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发表时间：
2022-07
影响因子：
17.8
通讯作者：
Skowronska-Krawczyk, Dorota
中科院分区：
文献类型：
--
作者：
Lewandowski, Dominik;Sander, Christopher L.;Tworak, Aleksander;Gao, Fangyuan;Xu, Qianlan;Skowronska-Krawczyk, Dorota
关键词：
视网膜色素上皮细胞-光感受器相互作用是自然界中研究最多的细胞-细胞界面之一。虽然光感受器使用光敏色素将光转化为电信号，但RPE通过吞噬脱落的光感受器尖端、调节血视网膜屏障和调节炎症反应以及经由经典视觉周期再生11-顺式视网膜发色团来支持光感受器的功能。这些过程涉及多种蛋白质复合物、严格调节的配体-受体相互作用以及过多的脂质和蛋白质-脂质相互作用。脂质在维持RPE和光感受器之间的健康相互作用中的作用尚未完全阐明。近年来，新技术在理解这种相互作用的几个方面取得了重大进展，包括脂质参与吞噬作用和吞噬溶酶体功能，营养循环以及两种细胞类型之间的代谢依赖性。在这篇综述中，我们的目标是整合光感受器和RPE功能中脂质的复杂作用，强调细胞之间的动态交换，并讨论这些过程如何在衰老和视网膜疾病中受到影响。
The retinal pigment epithelium-photoreceptor interaction is one of the most studied cell-to-cell interfaces in nature. While photoreceptors use photosensitive pigments to convert light into electrical signals, the RPE supports photoreceptors in their function by phagocytizing shed photoreceptor tips, regulating the blood-retina barrier, and modulating inflammatory responses, as well as regenerating the 11-cis-retinal chromophore via the classical visual cycle. These processes involve multiple protein complexes, tightly regulated ligand-receptors interactions, and a plethora of lipids and protein-lipids interactions. The role of lipids in maintaining a healthy interplay between the RPE and photoreceptors has not been fully delineated. In recent years, novel technologies have resulted in major advancements in understanding several facets of this interplay, including the involvement of lipids in phagocytosis and phagolysosome function, nutrient recycling, and the metabolic dependence between the two cell types. In this review, we aim to integrate the complex role of lipids in photoreceptor and RPE function, emphasizing the dynamic exchange between the cells as well as discuss how these processes are affected in aging and retinal diseases.
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影响因子：
4.6
作者：
Anderson DMG;Ablonczy Z;Koutalos Y;Hanneken AM;Spraggins JM;Calcutt MW;Crouch RK;Caprioli RM;Schey KL
通讯作者：
Schey KL
冻结裂纹证据证明了基底盘的无颗粒斑块以及小鼠和青蛙的视网膜外部片段的质膜中存在胆固醇。
影响因子：
7.8
作者：
Andrews, L D;Cohen, A I
通讯作者：
Cohen, A I
影响因子：
2
作者：
ANDERSON, RE;RAPP, LM;WIEGAND, RD
通讯作者：
WIEGAND, RD
影响因子：
2.9
作者：
Fincher J;Whiteneck C;Birgbauer E
通讯作者：
Birgbauer E
影响因子：
56.9
作者：
Acharya, U;Patel, S;Acharya, JK
通讯作者：
Acharya, JK