On your mark, get set:: Brainstem circuitry underlying saccadic initiation
On your mark, get set:: Brainstem circuitry underlying saccadic initiation
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DOI：
10.1139/cjpp-78-11-934
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发表时间：
2000-11-01
影响因子：
2.1
通讯作者：
Everling, S
中科院分区：
文献类型：
--
作者：
Munoz, DP;Dorris, MC;Everling, S
眼跳是一种快速的眼球运动，用于将视轴移动到视野中感兴趣的目标。启动扫视的时间取决于许多因素。在这里，我们回顾了一些最新的进展，在我们的理解这些过程在灵长类动物。上丘和脑干网状结构中的神经元被组织成一个网络来控制眼跳。一些神经元在视觉注视期间活跃，而另一些神经元在眼跳的准备和执行过程中活跃。在出现新的扫视靶点之前，有几个因素可以影响这些神经元的兴奋性水平。这些目标前兴奋性的变化与随后的行为表现变化相关。我们的结果展示了上丘和脑干网状结构中的神经元信号如何受到环境因素的影响，并展示了情景体验如何通过高级运动程序准备来加速运动行为。
Saccades are rapid eye movements that are used to move the visual axis toward targets of interest in the visual field. The time to initiate a saccade is dependent upon many factors. Here we review some of the recent advances in our understanding of the these processes in primates. Neurons in the superior colliculus and brainstem reticular formation are organised into a network to control saccades. Some neurons are active during visual fixation, while others are active during the preparation and execution of saccades. Several factors can influence the excitability levels of these neurons prior to the appearance of a new saccadic target. These pre-target changes in excitability are correlated to subsequent changes in behavioural performance. Our results show how neuronal signals in the superior colliculus and brainstem reticular formation can be shaped by contextual factors and demonstrate how situational experience can expedite motor behaviour via the advanced preparation of motor programs.