Comparison of[18F]FDG-PET, [99mTc]-HMPAO-SPECT, and [123I]-iomazenil-SPECT in localising the epileptogenic cortex
Comparison of[18F]FDG-PET, [99mTc]-HMPAO-SPECT, and [123I]-iomazenil-SPECT in localising the epileptogenic cortex
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[18F]FDG-PET、[99mTc]-HMPAO-SPECT 和 [123I]-iomazenil-SPECT 在定位致癫痫皮质方面的比较
DOI：
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发表时间：
1997
影响因子：
11
通讯作者：
Juha O. Rinne
中科院分区：
文献类型：
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作者：
S. Lamusuo;H. Ruottinen;J. Knuuti;R. Härkönen;U. Ruotsalainen;J. Bergman;M. Haaparanta;O. Solin;E. Mervaala;U. Nousiainen;S. Jääskeläinen;A. Ylinen;R. Kälviäinen;J. Rinne;M. Vapalahti;Juha O. Rinne
首先，比较发作间期18F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）和使用99 mTc-六甲基丙烯胺肟（HMPAO）和123 I-碘马唑胺（123 I-iomazenil）的单光子发射计算机断层扫描（SPECT）在定位癫痫手术候选人的致痫皮质中的结果，但在这些患者中，临床结果、视频EEG监测（V-EEG）、MRI、神经心理学评估没有给出癫痫发作的任何明确定位。其次，评估这些功能方法的能力，以帮助决定有关癫痫手术。方法对18例癫痫患者进行FDG-PET和Iomazenil-SPECT检查。在这18例患者中，11例进行了HMPAO-SPECT。两个参考定位使用发作硬膜下脑电图记录（S-EEG）和手术区域。结果18例患者中15例在S-EEG上有定位发现。13例患者的FDG-PET结果与参考文献一致，9例患者的iomazenil-SPECT结果与参考文献一致。HMPAO-SPECT显示病灶的准确性低于其他两种方法。在3例患者中，S-EEG显示独立的双颞癫痫发作。在这些患者中，FDG-PET显示无偏侧化。然而，碘马替尼-SPECT显示颞叶偏侧在其中两个。结论FDG-PET对复杂局灶性癫痫患者致痫皮质的定位较Iomazenil-SPECT更准确。
OBJECTIVES Firstly, to compare the findings of interictal 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and of single photon emission computed tomography (SPECT) using 99mTc-hexamethyl propylene-amine-oxime (HMPAO) and 123I-iomazenil in localising the epileptogenic cortex in patients who were candidates for epilepsy surgery, but in whom clinical findings, video EEG monitoring (V-EEG), MRI, and neuropsychological evaluations did not give any definite localisation of the seizure onset. Secondly, to assess the ability of these functional methods to help in the decision about the epilepsy surgery. METHODS Eighteen epileptic patients were studied with FDG-PET and iomazenil-SPECT. HMPAO-SPECT was performed in 11 of these 18 patients. Two references for localisation was used—ictal subdural EEG recordings (S-EEG) and the operated region. RESULTS Fifteen of 18 patients had localising findings in S-EEG. FDG-PET findings were in accordance with the references in 13 patients and iomazenil-SPECT in nine patients. HMPAO-SPECT visualised the focus less accurately than the two other methods. In three patients S-EEG showed independent bitemporal seizure onset. In these patients FDG-PET showed no lateralisation. However, iomazenil-SPECT showed temporal lobe lateralisation in two of them. CONCLUSION FDG-PET seemed to localise the epileptogenic cortex more accurately than interictal iomazenil-SPECT in patients with complicated focal epilepsy.
发作间期氟-18-氟脱氧葡萄糖 PET 在部分性癫痫中的临床评价。
DOI：
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发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
Henry,TR;EngelJr,J;Mazziotta,JC
通讯作者：
Mazziotta,JC