The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis
The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis
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DOI：
10.1152/ajpendo.00038.2010
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发表时间：
2010-11-01
影响因子：
5.1
通讯作者：
Baar, Keith
中科院分区：
文献类型：
--
作者：
Deldicque, Louise;Cani, Patrice D.;Baar, Keith
2005年10月27日，李国伟.高脂喂养激活骨骼肌中未折叠蛋白反应：蛋白质合成下调的潜在作用。美国生理学杂志内分泌代谢299：E695-E705，2010年。首次发表于2010年5月25日; doi：10.1152/ajpendo.00038.2010.-众所周知，高脂肪饮食会降低肌肉蛋白质合成、对超负荷的适应和胰岛素敏感性。破坏内质网（ER）稳态的条件导致未折叠蛋白反应（UPR）的激活，这与蛋白质合成减少、慢性炎症和胰岛素抵抗有关。本研究的目的是确定ER应激是否由骨骼肌中的高脂饮食诱导，以及ER应激是否可以降低肌细胞中mTORC 1活性和蛋白质合成。两种独立的高脂喂养方案激活了小鼠的UPR。在第一项研究中，小鼠食用含有70%脂肪的高脂肪饮食，
Deldicque L, Cani PD, Philp A, Raymackers JM, Meakin PJ, Ashford ML, Delzenne NM, Francaux M, Baar K. The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis. Am J Physiol Endocrinol Metab 299: E695-E705, 2010. First published May 25, 2010; doi: 10.1152/ajpendo.00038.2010.-High-fat diets are known to decrease muscle protein synthesis, the adaptation to overload, and insulin sensitivity. Conditions that disrupt endoplasmic reticulum (ER) homeostasis lead to the activation of the unfolded protein response (UPR) that is associated with decreases in protein synthesis, chronic inflammation, and insulin resistance. The purpose of the present study was to establish whether ER stress is induced by a high-fat diet in skeletal muscle and whether ER stress can decrease mTORC1 activity and protein synthesis in muscle cells. Two independent protocols of high-fat feeding activated the UPR in mice. In the first study, mice consuming a high-fat diet containing 70% fat and